Bioequivalence of budesonide plus formoterol (BF) Spiromax® and BF Turbohaler® (with and without charcoal block) in healthy volunteers

Budesonide formoterol (BF) Spiromax® is a breath-actuated dry-powder inhaler designed to deliver similar combinations of budesonide and formoterol as Symbicort® Turbohaler®. We performed two studies to demonstrate pharmacokinetic (PK) equivalence of BF Spiromax with BF Turbohaler. Two single-center,...

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Veröffentlicht in:	International journal of clinical pharmacology and therapeutics 2015-07, Vol.53 (7), p.593-602
Hauptverfasser:	Weisfeld, Lori, Shu, Youyi, Shah, Tushar P
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenergic beta-2 Receptor Agonists - administration & dosage Adrenergic beta-2 Receptor Agonists - adverse effects Adrenergic beta-2 Receptor Agonists - blood Adrenergic beta-2 Receptor Agonists - pharmacokinetics Adult Bronchodilator Agents - administration & dosage Bronchodilator Agents - adverse effects Bronchodilator Agents - blood Bronchodilator Agents - pharmacokinetics Budesonide - administration & dosage Budesonide - adverse effects Budesonide - blood Budesonide - pharmacokinetics Charcoal Cross-Over Studies Drug Combinations Dry Powder Inhalers Equipment Design Ethanolamines - administration & dosage Ethanolamines - adverse effects Ethanolamines - blood Ethanolamines - pharmacokinetics Female Formoterol Fumarate Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Glucocorticoids - blood Glucocorticoids - pharmacokinetics Healthy Volunteers Humans Male Therapeutic Equivalency Young Adult
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