Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents
Background: Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition in utero among pregnant adolescents. Objective: To determine whether maternal pre-pregnancy BMI (ppBM...
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| Veröffentlicht in: | International Journal of Obesity 2015-04, Vol.39 (4), p.565-570 |
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| creator | Whisner, C M Young, B E Pressman, E K Queenan, R A Cooper, E M O'Brien, K O |
| description | Background:
Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition
in utero
among pregnant adolescents.
Objective:
To determine whether maternal pre-pregnancy BMI (ppBMI), gestational weight gain (GWG) and dietary intake during pregnancy influence fetal fat accretion
in utero
.
Methods:
Longitudinal data were obtained from 121 pregnant adolescents enrolled in a study designed to identify determinants of maternal and fetal bone changes across gestation. Adolescents (ages 13–18 years) completed up to three study visits during early, mid- and late gestation. Maternal anthropometrics, 24 h dietary recalls and measures of fetal biometry were obtained at each visit. Fetal abdominal wall thickness (abdominal subcutaneous fat thickness, AbFat), a measure of fetal subcutaneous fat, was calculated by sonography at each visit. Statistical determinants of AbFat during late pregnancy were explored using simple and multiple regression.
Results:
During late pregnancy (34.8±2.0 weeks; range 31.0–40.6 weeks of gestation), the median (inter-quartile range) fetal AbFat and GWG were 0.44 (0.39, 0.55) cm and 14.6 (9.5, 18.3) kg, respectively. After adjusting for infant birth weight, variables significantly associated with fetal AbFat included gestational age (
P |
| doi_str_mv | 10.1038/ijo.2014.202 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1691290785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A410642747</galeid><sourcerecordid>A410642747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c586t-46800661d93f6d1a4cd86cdb90c03def3d57d259e8080b1d0ebee95f8210fa243</originalsourceid><addsrcrecordid>eNp9kt-L1DAQx4Mo3nr65rMUBPHBrpM0SdvH4_AXnPiizyFNpt0s3WRNUuX-e1P21Ds5JDCBmc93fjGEPKewpdB0b90-bBlQXgx7QDaUt7IWvG8fkg000NYgpDgjT1LaA4AQwB6TMya47DrWbsiPzzpj9HqurMNcDUuufMjVhCnr7MIa-Ilu2hWXdr46RrTO5FQZ9DmWoLbuGJLL15U2JuIqqQq3lKSh0ofgp1Uzee1zYcOMaVWmp-TRqOeEz27-c_Lt_buvlx_rqy8fPl1eXNVGdDLXpUsAKantm1FaqrmxnTR26MFAY3FsrGgtEz120MFALeCA2IuxYxRGzXhzTl6f8h5j-L6UodTBlQ7mWXsMS1JU9pT10HaioC__QfdhWTeTFGsaKlkr5X8pKlsodSnv_1KTnlE5P4ayLLOWVhecguSs5W2htvdQ5Vk8OBM8jq747whe3RLsUM95l8K8rFtPd8E3J9DEkFLEUR2jO-h4rSio9WpUuRq1Xk0xrOAvboZahgPaP_DvMylAfQJSCfkJ462p70v4C6qkymE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1670210149</pqid></control><display><type>article</type><title>Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><creator>Whisner, C M ; Young, B E ; Pressman, E K ; Queenan, R A ; Cooper, E M ; O'Brien, K O</creator><creatorcontrib>Whisner, C M ; Young, B E ; Pressman, E K ; Queenan, R A ; Cooper, E M ; O'Brien, K O</creatorcontrib><description>Background:
Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition
in utero
among pregnant adolescents.
Objective:
To determine whether maternal pre-pregnancy BMI (ppBMI), gestational weight gain (GWG) and dietary intake during pregnancy influence fetal fat accretion
in utero
.
Methods:
Longitudinal data were obtained from 121 pregnant adolescents enrolled in a study designed to identify determinants of maternal and fetal bone changes across gestation. Adolescents (ages 13–18 years) completed up to three study visits during early, mid- and late gestation. Maternal anthropometrics, 24 h dietary recalls and measures of fetal biometry were obtained at each visit. Fetal abdominal wall thickness (abdominal subcutaneous fat thickness, AbFat), a measure of fetal subcutaneous fat, was calculated by sonography at each visit. Statistical determinants of AbFat during late pregnancy were explored using simple and multiple regression.
Results:
During late pregnancy (34.8±2.0 weeks; range 31.0–40.6 weeks of gestation), the median (inter-quartile range) fetal AbFat and GWG were 0.44 (0.39, 0.55) cm and 14.6 (9.5, 18.3) kg, respectively. After adjusting for infant birth weight, variables significantly associated with fetal AbFat included gestational age (
P
<0.0001, 95% confidence interval, CI: 0.01, 0.03), maternal race (
P
=0.029, 95% CI: −0.04, −0.002) and dietary intake of added sugar (
P
=0.025, 95% CI: 1.42e–6, 2.06e–5). Fetal AbFat had a significant positive quadratic relationship with total maternal dietary sugar intake such that both low and high extremes of sugar consumption were associated with significantly higher fetal AbFat. Birth weight was not significantly associated with maternal intake of added sugars.
Conclusion:
Extreme sugar intakes among pregnant adolescents may lead to increased accumulation of fetal abdominal fat with little net effect on birth weight. This finding suggests that increased sugar consumption during pregnancy promotes shifts in fetal body composition.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2014.202</identifier><identifier>PMID: 25468827</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/700/2814 ; Abdomen ; Abdominal wall ; Accretion ; Adipose tissue ; Adolescent ; Adolescents ; Birth Weight ; Body Composition ; Body mass index ; Body weight gain ; Childbirth & labor ; Confidence intervals ; Deposition ; Diabetes ; Diet ; Dietary Carbohydrates - adverse effects ; Dietary intake ; Dietary Sucrose - adverse effects ; Epidemiology ; Ethnicity ; Feeding Behavior ; Female ; Fetuses ; Food intake ; Gestation ; Gestational age ; Health aspects ; Health Promotion and Disease Prevention ; Health risk assessment ; Hispanic people ; Humans ; Internal Medicine ; Lipid metabolism ; Longitudinal studies ; Maternal Nutritional Physiological Phenomena ; Mathematical analysis ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrition research ; Obesity ; Obesity, Abdominal - epidemiology ; Obesity, Abdominal - prevention & control ; pediatric-original-article ; Pregnancy ; Pregnancy Complications - etiology ; Pregnancy Complications - prevention & control ; Pregnant Women ; Public Health ; Risk analysis ; Risk Factors ; Self report ; Statistical analysis ; Sugar ; Teenage pregnancy ; Teenagers ; Thickness measurement ; Wall thickness ; Weight Gain ; Womens health</subject><ispartof>International Journal of Obesity, 2015-04, Vol.39 (4), p.565-570</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2015</rights><rights>Macmillan Publishers Limited 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-46800661d93f6d1a4cd86cdb90c03def3d57d259e8080b1d0ebee95f8210fa243</citedby><cites>FETCH-LOGICAL-c586t-46800661d93f6d1a4cd86cdb90c03def3d57d259e8080b1d0ebee95f8210fa243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2014.202$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2014.202$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27913,27914,41477,42546,51308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25468827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whisner, C M</creatorcontrib><creatorcontrib>Young, B E</creatorcontrib><creatorcontrib>Pressman, E K</creatorcontrib><creatorcontrib>Queenan, R A</creatorcontrib><creatorcontrib>Cooper, E M</creatorcontrib><creatorcontrib>O'Brien, K O</creatorcontrib><title>Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background:
Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition
in utero
among pregnant adolescents.
Objective:
To determine whether maternal pre-pregnancy BMI (ppBMI), gestational weight gain (GWG) and dietary intake during pregnancy influence fetal fat accretion
in utero
.
Methods:
Longitudinal data were obtained from 121 pregnant adolescents enrolled in a study designed to identify determinants of maternal and fetal bone changes across gestation. Adolescents (ages 13–18 years) completed up to three study visits during early, mid- and late gestation. Maternal anthropometrics, 24 h dietary recalls and measures of fetal biometry were obtained at each visit. Fetal abdominal wall thickness (abdominal subcutaneous fat thickness, AbFat), a measure of fetal subcutaneous fat, was calculated by sonography at each visit. Statistical determinants of AbFat during late pregnancy were explored using simple and multiple regression.
Results:
During late pregnancy (34.8±2.0 weeks; range 31.0–40.6 weeks of gestation), the median (inter-quartile range) fetal AbFat and GWG were 0.44 (0.39, 0.55) cm and 14.6 (9.5, 18.3) kg, respectively. After adjusting for infant birth weight, variables significantly associated with fetal AbFat included gestational age (
P
<0.0001, 95% confidence interval, CI: 0.01, 0.03), maternal race (
P
=0.029, 95% CI: −0.04, −0.002) and dietary intake of added sugar (
P
=0.025, 95% CI: 1.42e–6, 2.06e–5). Fetal AbFat had a significant positive quadratic relationship with total maternal dietary sugar intake such that both low and high extremes of sugar consumption were associated with significantly higher fetal AbFat. Birth weight was not significantly associated with maternal intake of added sugars.
Conclusion:
Extreme sugar intakes among pregnant adolescents may lead to increased accumulation of fetal abdominal fat with little net effect on birth weight. This finding suggests that increased sugar consumption during pregnancy promotes shifts in fetal body composition.</description><subject>692/499</subject><subject>692/700/2814</subject><subject>Abdomen</subject><subject>Abdominal wall</subject><subject>Accretion</subject><subject>Adipose tissue</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Birth Weight</subject><subject>Body Composition</subject><subject>Body mass index</subject><subject>Body weight gain</subject><subject>Childbirth & labor</subject><subject>Confidence intervals</subject><subject>Deposition</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Dietary Carbohydrates - adverse effects</subject><subject>Dietary intake</subject><subject>Dietary Sucrose - adverse effects</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Fetuses</subject><subject>Food intake</subject><subject>Gestation</subject><subject>Gestational age</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risk assessment</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipid metabolism</subject><subject>Longitudinal studies</subject><subject>Maternal Nutritional Physiological Phenomena</subject><subject>Mathematical analysis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Obesity, Abdominal - epidemiology</subject><subject>Obesity, Abdominal - prevention & control</subject><subject>pediatric-original-article</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - etiology</subject><subject>Pregnancy Complications - prevention & control</subject><subject>Pregnant Women</subject><subject>Public Health</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Self report</subject><subject>Statistical analysis</subject><subject>Sugar</subject><subject>Teenage pregnancy</subject><subject>Teenagers</subject><subject>Thickness measurement</subject><subject>Wall thickness</subject><subject>Weight Gain</subject><subject>Womens health</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kt-L1DAQx4Mo3nr65rMUBPHBrpM0SdvH4_AXnPiizyFNpt0s3WRNUuX-e1P21Ds5JDCBmc93fjGEPKewpdB0b90-bBlQXgx7QDaUt7IWvG8fkg000NYgpDgjT1LaA4AQwB6TMya47DrWbsiPzzpj9HqurMNcDUuufMjVhCnr7MIa-Ilu2hWXdr46RrTO5FQZ9DmWoLbuGJLL15U2JuIqqQq3lKSh0ofgp1Uzee1zYcOMaVWmp-TRqOeEz27-c_Lt_buvlx_rqy8fPl1eXNVGdDLXpUsAKantm1FaqrmxnTR26MFAY3FsrGgtEz120MFALeCA2IuxYxRGzXhzTl6f8h5j-L6UodTBlQ7mWXsMS1JU9pT10HaioC__QfdhWTeTFGsaKlkr5X8pKlsodSnv_1KTnlE5P4ayLLOWVhecguSs5W2htvdQ5Vk8OBM8jq747whe3RLsUM95l8K8rFtPd8E3J9DEkFLEUR2jO-h4rSio9WpUuRq1Xk0xrOAvboZahgPaP_DvMylAfQJSCfkJ462p70v4C6qkymE</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Whisner, C M</creator><creator>Young, B E</creator><creator>Pressman, E K</creator><creator>Queenan, R A</creator><creator>Cooper, E M</creator><creator>O'Brien, K O</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>20150401</creationdate><title>Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents</title><author>Whisner, C M ; Young, B E ; Pressman, E K ; Queenan, R A ; Cooper, E M ; O'Brien, K O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-46800661d93f6d1a4cd86cdb90c03def3d57d259e8080b1d0ebee95f8210fa243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/499</topic><topic>692/700/2814</topic><topic>Abdomen</topic><topic>Abdominal wall</topic><topic>Accretion</topic><topic>Adipose tissue</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Birth Weight</topic><topic>Body Composition</topic><topic>Body mass index</topic><topic>Body weight gain</topic><topic>Childbirth & labor</topic><topic>Confidence intervals</topic><topic>Deposition</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Dietary Carbohydrates - adverse effects</topic><topic>Dietary intake</topic><topic>Dietary Sucrose - adverse effects</topic><topic>Epidemiology</topic><topic>Ethnicity</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Fetuses</topic><topic>Food intake</topic><topic>Gestation</topic><topic>Gestational age</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risk assessment</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipid metabolism</topic><topic>Longitudinal studies</topic><topic>Maternal Nutritional Physiological Phenomena</topic><topic>Mathematical analysis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Obesity, Abdominal - epidemiology</topic><topic>Obesity, Abdominal - prevention & control</topic><topic>pediatric-original-article</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - etiology</topic><topic>Pregnancy Complications - prevention & control</topic><topic>Pregnant Women</topic><topic>Public Health</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Self report</topic><topic>Statistical analysis</topic><topic>Sugar</topic><topic>Teenage pregnancy</topic><topic>Teenagers</topic><topic>Thickness measurement</topic><topic>Wall thickness</topic><topic>Weight Gain</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whisner, C M</creatorcontrib><creatorcontrib>Young, B E</creatorcontrib><creatorcontrib>Pressman, E K</creatorcontrib><creatorcontrib>Queenan, R A</creatorcontrib><creatorcontrib>Cooper, E M</creatorcontrib><creatorcontrib>O'Brien, K O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whisner, C M</au><au>Young, B E</au><au>Pressman, E K</au><au>Queenan, R A</au><au>Cooper, E M</au><au>O'Brien, K O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>39</volume><issue>4</issue><spage>565</spage><epage>570</epage><pages>565-570</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background:
Modifiable risk factors during pregnancy, such as diet and weight gain, are associated with fetal birth weight but little is known about how these factors influence fetal fat acquisition
in utero
among pregnant adolescents.
Objective:
To determine whether maternal pre-pregnancy BMI (ppBMI), gestational weight gain (GWG) and dietary intake during pregnancy influence fetal fat accretion
in utero
.
Methods:
Longitudinal data were obtained from 121 pregnant adolescents enrolled in a study designed to identify determinants of maternal and fetal bone changes across gestation. Adolescents (ages 13–18 years) completed up to three study visits during early, mid- and late gestation. Maternal anthropometrics, 24 h dietary recalls and measures of fetal biometry were obtained at each visit. Fetal abdominal wall thickness (abdominal subcutaneous fat thickness, AbFat), a measure of fetal subcutaneous fat, was calculated by sonography at each visit. Statistical determinants of AbFat during late pregnancy were explored using simple and multiple regression.
Results:
During late pregnancy (34.8±2.0 weeks; range 31.0–40.6 weeks of gestation), the median (inter-quartile range) fetal AbFat and GWG were 0.44 (0.39, 0.55) cm and 14.6 (9.5, 18.3) kg, respectively. After adjusting for infant birth weight, variables significantly associated with fetal AbFat included gestational age (
P
<0.0001, 95% confidence interval, CI: 0.01, 0.03), maternal race (
P
=0.029, 95% CI: −0.04, −0.002) and dietary intake of added sugar (
P
=0.025, 95% CI: 1.42e–6, 2.06e–5). Fetal AbFat had a significant positive quadratic relationship with total maternal dietary sugar intake such that both low and high extremes of sugar consumption were associated with significantly higher fetal AbFat. Birth weight was not significantly associated with maternal intake of added sugars.
Conclusion:
Extreme sugar intakes among pregnant adolescents may lead to increased accumulation of fetal abdominal fat with little net effect on birth weight. This finding suggests that increased sugar consumption during pregnancy promotes shifts in fetal body composition.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25468827</pmid><doi>10.1038/ijo.2014.202</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2015-04, Vol.39 (4), p.565-570 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1691290785 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | 692/499 692/700/2814 Abdomen Abdominal wall Accretion Adipose tissue Adolescent Adolescents Birth Weight Body Composition Body mass index Body weight gain Childbirth & labor Confidence intervals Deposition Diabetes Diet Dietary Carbohydrates - adverse effects Dietary intake Dietary Sucrose - adverse effects Epidemiology Ethnicity Feeding Behavior Female Fetuses Food intake Gestation Gestational age Health aspects Health Promotion and Disease Prevention Health risk assessment Hispanic people Humans Internal Medicine Lipid metabolism Longitudinal studies Maternal Nutritional Physiological Phenomena Mathematical analysis Medicine Medicine & Public Health Metabolic Diseases Nutrition research Obesity Obesity, Abdominal - epidemiology Obesity, Abdominal - prevention & control pediatric-original-article Pregnancy Pregnancy Complications - etiology Pregnancy Complications - prevention & control Pregnant Women Public Health Risk analysis Risk Factors Self report Statistical analysis Sugar Teenage pregnancy Teenagers Thickness measurement Wall thickness Weight Gain Womens health |
| title | Maternal diet but not gestational weight gain predicts central adiposity accretion in utero among pregnant adolescents |
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