Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement
The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are th...
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| Veröffentlicht in: | Biointerphases 2015-06, Vol.10 (2), p.021011-021011 |
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| container_title | Biointerphases |
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| creator | Danilevicius, Paulius Rezende, Rodrigo A Pereira, Frederico D A S Selimis, Alexandros Kasyanov, Vladimir Noritomi, Pedro Y da Silva, Jorge V L Chatzinikolaidou, Maria Farsari, Maria Mironov, Vladimir |
| description | The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. The scaffolds are made by multiphoton polymerization of an organic-inorganic zirconium silicate. Their mechanical properties are theoretically modeled using finite elements analysis and experimentally measured using a Microsquisher(®). They are subsequently loaded with preosteoblastic cells, which remain live after 24 and 72 h. The interlockable scaffolds have maintained their ability to fuse with tissue spheroids. This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication. |
| doi_str_mv | 10.1116/1.4922646 |
| format | Article |
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This work represents a novel technological platform, enabling the rapid, laser-based, in situ 3D tissue biofabrication.</description><subject>Animals</subject><subject>Cell Line</subject><subject>Cell Survival</subject><subject>Cells, Immobilized - physiology</subject><subject>Lasers</subject><subject>Mice</subject><subject>Osteoblasts - physiology</subject><subject>Polymerization</subject><subject>Silicates</subject><subject>Stem Cells - physiology</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds</subject><subject>Zirconium</subject><issn>1934-8630</issn><issn>1559-4106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURS0EoqUw8AeQR5BI8fNX4hEKBaRKLDBbjvMMgaQpdjLw70nVwvTucHR13yHkHNgcAPQNzKXhXEt9QKaglMkkMH04ZiNkVmjBJuQkpU_GpFJaHJMJ18AkGDYly7shxqypv_CaNi5hzFpXIRX3tK197JJ3IXRNlWjoIu3rlAakafOBsasrimvv3rHFdX9KjoJrEp7t74y8LR9eF0_Z6uXxeXG7yjwvVJ-5fNxQeu-q4I0wLJgqcCddPo4uc-Ald0oxZwrDXQFGlrnMcyww6ABCFCBm5HLXu4nd94Cpt22dPDaNW2M3JAvaAC8MaDaiVzt0-0aKGOwm1q2LPxaY3WqzYPfaRvZiXzuULVb_5J8n8QvaxWXx</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Danilevicius, Paulius</creator><creator>Rezende, Rodrigo A</creator><creator>Pereira, Frederico D A S</creator><creator>Selimis, Alexandros</creator><creator>Kasyanov, Vladimir</creator><creator>Noritomi, Pedro Y</creator><creator>da Silva, Jorge V L</creator><creator>Chatzinikolaidou, Maria</creator><creator>Farsari, Maria</creator><creator>Mironov, Vladimir</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement</title><author>Danilevicius, Paulius ; Rezende, Rodrigo A ; Pereira, Frederico D A S ; Selimis, Alexandros ; Kasyanov, Vladimir ; Noritomi, Pedro Y ; da Silva, Jorge V L ; Chatzinikolaidou, Maria ; Farsari, Maria ; Mironov, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-a7004bccadfc9390f9df2a4a7559b712b2a550a9892a8194b7477e8ef6f133813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>Cell Survival</topic><topic>Cells, Immobilized - physiology</topic><topic>Lasers</topic><topic>Mice</topic><topic>Osteoblasts - physiology</topic><topic>Polymerization</topic><topic>Silicates</topic><topic>Stem Cells - physiology</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Danilevicius, Paulius</creatorcontrib><creatorcontrib>Rezende, Rodrigo A</creatorcontrib><creatorcontrib>Pereira, Frederico D A S</creatorcontrib><creatorcontrib>Selimis, Alexandros</creatorcontrib><creatorcontrib>Kasyanov, Vladimir</creatorcontrib><creatorcontrib>Noritomi, Pedro Y</creatorcontrib><creatorcontrib>da Silva, Jorge V L</creatorcontrib><creatorcontrib>Chatzinikolaidou, Maria</creatorcontrib><creatorcontrib>Farsari, Maria</creatorcontrib><creatorcontrib>Mironov, Vladimir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biointerphases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Danilevicius, Paulius</au><au>Rezende, Rodrigo A</au><au>Pereira, Frederico D A S</au><au>Selimis, Alexandros</au><au>Kasyanov, Vladimir</au><au>Noritomi, Pedro Y</au><au>da Silva, Jorge V L</au><au>Chatzinikolaidou, Maria</au><au>Farsari, Maria</au><au>Mironov, Vladimir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement</atitle><jtitle>Biointerphases</jtitle><addtitle>Biointerphases</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>021011</spage><epage>021011</epage><pages>021011-021011</pages><issn>1934-8630</issn><eissn>1559-4106</eissn><abstract>The modeling, fabrication, cell loading, and mechanical and in vitro biological testing of biomimetic, interlockable, laser-made, concentric 3D scaffolds are presented. 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| ispartof | Biointerphases, 2015-06, Vol.10 (2), p.021011-021011 |
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| language | eng |
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| source | MEDLINE; AIP Journals Complete; Alma/SFX Local Collection |
| subjects | Animals Cell Line Cell Survival Cells, Immobilized - physiology Lasers Mice Osteoblasts - physiology Polymerization Silicates Stem Cells - physiology Tissue Engineering - methods Tissue Scaffolds Zirconium |
| title | Burr-like, laser-made 3D microscaffolds for tissue spheroid encagement |
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