Task persistence and learning ability in normal and chronic low dose MPTP-treated monkeys

Monkeys exposed to low doses of the dopamine neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) develop cognitive deficits in the absence of gross motor dysfunction. Attentional deficits and task impersistence are now also described in these animals. The task impersistence correlated wit...

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Veröffentlicht in:	Behavioural brain research 1994-02, Vol.60 (2), p.115-124
Hauptverfasser:	Roeltgen, David P., Schneider, Jay S.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology Animals Appetitive Behavior - drug effects Appetitive Behavior - physiology Attention - drug effects Behavioral psychophysiology Biological and medical sciences Discrimination Learning - drug effects Discrimination Learning - physiology Dopamine - physiology Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Learning ability Macaca fascicularis Macaca mulatta Macaca nemestrina Male Mental Recall - drug effects Monkey Motivation MPTP Neurotransmission and behavior Parkinson's disease Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychomotor Performance - drug effects Psychomotor Performance - physiology Reaction Time - drug effects Reaction Time - physiology Task persistence
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