Regulation of human dioxin receptor function by indolocarbazoles, receptor ligands of dietary origin

The intracellular basic helix-loop-helix (bHLH) dioxin receptor mediates signal transduction by dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin). In analogy to nuclear receptors that are members of the steroid hormone receptor superfamily the dioxin receptor is a ligand-inducible transcriptional regulat...

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Veröffentlicht in:	The Journal of biological chemistry 1994-02, Vol.269 (7), p.5137-5144
Hauptverfasser:	KLEMAN, M. I, POELLINGER, L, GUSTAFSSON, J.-Å
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbazoles - pharmacology Carcinoma, Hepatocellular - metabolism Cell Line Cell receptors Cell structures and functions Diet Dimethyl Sulfoxide - pharmacology DNA-Binding Proteins - drug effects DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Helix-Loop-Helix Motifs Humans Indoles - pharmacology Kinetics Liver Neoplasms - metabolism Mice Miscellaneous Molecular and cellular biology Polychlorinated Dibenzodioxins - pharmacology Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism Signal Transduction Structure-Activity Relationship Transfection Tumor Cells, Cultured
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