Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants
We present a new hygroscopic implant material which consists of high-molecular-weight polyacrylic acid (PAA) as a filler in a Silastic R matrix. The mixture swells upon immersion in bodily fluids; the degree of swelling depends on the ratio of PAA to Silastic and allows the design of implants that w...
Gespeichert in:
| Veröffentlicht in: | Biomaterials 1994-11, Vol.15 (14), p.1161-1169 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1169 |
|---|---|
| container_issue | 14 |
| container_start_page | 1161 |
| container_title | Biomaterials |
| container_volume | 15 |
| creator | Seldon, H.L. Dahm, M.C. Clark, G.M. Crowe, S. |
| description | We present a new hygroscopic implant material which consists of high-molecular-weight polyacrylic acid (PAA) as a filler in a Silastic
R matrix. The mixture swells upon immersion in bodily fluids; the degree of swelling depends on the ratio of PAA to Silastic and allows the design of implants that will achieve their final shape and size only after the implantation procedure.
In vivo and
in vitro biocompatibility tests reveal no adverse cellular or tissue responses. In cochlear implant development the material has been experimentally incorporated into intracochlear electrode arrays which curl after insertion, and in bacteriostatic devices for electrode fixation. |
| doi_str_mv | 10.1016/0142-9612(94)90237-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16911757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0142961294902372</els_id><sourcerecordid>16911757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-60d25e7d6570924545e9f6642be8a4e61f9fbe03b2fc433cf7c048f9643abad53</originalsourceid><addsrcrecordid>eNp9kE2LFDEQhoMo67j6DxRyEFGwNV-d7uxBkEV3hQUP6jmk0xW3JP1hktll_r0ZZ5jjnopUPfVSeQh5ydkHzrj-yLgSjdFcvDXqnWFCdo14RDa87_qmNax9TDYn5Cl5lvMfVt9MiTNy1vVGGm42JP_A6HJBT--x3NJ1iTvn0y7WhvM40oAxQrqg-R5ixPk3XdOyQioI-T0dcPHLtLqCA0YsO-rmsUYUmAu6SLcZKM7UL_42gksUpzW6ueTn5ElwMcOLYz0nv75--Xl53dx8v_p2-fmm8Yp3pdFsFC10o247ZoRqVQsmaK3EAL1ToHkwYQAmBxG8ktKHzjPVB6OVdIMbW3lO3hxy681_t5CLnTD7-g83w7LNlmvDedd2FVQH0Kcl5wTBrgknl3aWM7t3bfci7V6kNcr-d21FXXt1zN8OE4ynpaPcOn99nLvsXQzJzR7zCZNSKtGyin06YFBd3CEkmz3C7GHEBL7YccGH7_gHz92cwg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16911757</pqid></control><display><type>article</type><title>Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Seldon, H.L. ; Dahm, M.C. ; Clark, G.M. ; Crowe, S.</creator><creatorcontrib>Seldon, H.L. ; Dahm, M.C. ; Clark, G.M. ; Crowe, S.</creatorcontrib><description>We present a new hygroscopic implant material which consists of high-molecular-weight polyacrylic acid (PAA) as a filler in a Silastic
R matrix. The mixture swells upon immersion in bodily fluids; the degree of swelling depends on the ratio of PAA to Silastic and allows the design of implants that will achieve their final shape and size only after the implantation procedure.
In vivo and
in vitro biocompatibility tests reveal no adverse cellular or tissue responses. In cochlear implant development the material has been experimentally incorporated into intracochlear electrode arrays which curl after insertion, and in bacteriostatic devices for electrode fixation.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/0142-9612(94)90237-2</identifier><identifier>PMID: 7893919</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acrylic Resins - adverse effects ; Acrylic Resins - chemistry ; Analysis of Variance ; Animals ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Body Fluids - metabolism ; Cats ; Cells, Cultured ; Cochlea - drug effects ; Cochlea - pathology ; Cochlea - ultrastructure ; Cochlear implant ; Cochlear Implants ; Humans ; hydrogel ; implant material ; Macrophages - cytology ; Macrophages - drug effects ; Macrophages - ultrastructure ; Medical sciences ; Microelectrodes ; Microscopy, Electron, Scanning ; Molecular Weight ; Orthopedic surgery ; Regression Analysis ; Silicone Elastomers - adverse effects ; Silicone Elastomers - chemistry ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><ispartof>Biomaterials, 1994-11, Vol.15 (14), p.1161-1169</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-60d25e7d6570924545e9f6642be8a4e61f9fbe03b2fc433cf7c048f9643abad53</citedby><cites>FETCH-LOGICAL-c417t-60d25e7d6570924545e9f6642be8a4e61f9fbe03b2fc433cf7c048f9643abad53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0142961294902372$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3334250$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7893919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seldon, H.L.</creatorcontrib><creatorcontrib>Dahm, M.C.</creatorcontrib><creatorcontrib>Clark, G.M.</creatorcontrib><creatorcontrib>Crowe, S.</creatorcontrib><title>Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>We present a new hygroscopic implant material which consists of high-molecular-weight polyacrylic acid (PAA) as a filler in a Silastic
R matrix. The mixture swells upon immersion in bodily fluids; the degree of swelling depends on the ratio of PAA to Silastic and allows the design of implants that will achieve their final shape and size only after the implantation procedure.
In vivo and
in vitro biocompatibility tests reveal no adverse cellular or tissue responses. In cochlear implant development the material has been experimentally incorporated into intracochlear electrode arrays which curl after insertion, and in bacteriostatic devices for electrode fixation.</description><subject>Acrylic Resins - adverse effects</subject><subject>Acrylic Resins - chemistry</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Body Fluids - metabolism</subject><subject>Cats</subject><subject>Cells, Cultured</subject><subject>Cochlea - drug effects</subject><subject>Cochlea - pathology</subject><subject>Cochlea - ultrastructure</subject><subject>Cochlear implant</subject><subject>Cochlear Implants</subject><subject>Humans</subject><subject>hydrogel</subject><subject>implant material</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - ultrastructure</subject><subject>Medical sciences</subject><subject>Microelectrodes</subject><subject>Microscopy, Electron, Scanning</subject><subject>Molecular Weight</subject><subject>Orthopedic surgery</subject><subject>Regression Analysis</subject><subject>Silicone Elastomers - adverse effects</subject><subject>Silicone Elastomers - chemistry</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo67j6DxRyEFGwNV-d7uxBkEV3hQUP6jmk0xW3JP1hktll_r0ZZ5jjnopUPfVSeQh5ydkHzrj-yLgSjdFcvDXqnWFCdo14RDa87_qmNax9TDYn5Cl5lvMfVt9MiTNy1vVGGm42JP_A6HJBT--x3NJ1iTvn0y7WhvM40oAxQrqg-R5ixPk3XdOyQioI-T0dcPHLtLqCA0YsO-rmsUYUmAu6SLcZKM7UL_42gksUpzW6ueTn5ElwMcOLYz0nv75--Xl53dx8v_p2-fmm8Yp3pdFsFC10o247ZoRqVQsmaK3EAL1ToHkwYQAmBxG8ktKHzjPVB6OVdIMbW3lO3hxy681_t5CLnTD7-g83w7LNlmvDedd2FVQH0Kcl5wTBrgknl3aWM7t3bfci7V6kNcr-d21FXXt1zN8OE4ynpaPcOn99nLvsXQzJzR7zCZNSKtGyin06YFBd3CEkmz3C7GHEBL7YccGH7_gHz92cwg</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>Seldon, H.L.</creator><creator>Dahm, M.C.</creator><creator>Clark, G.M.</creator><creator>Crowe, S.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19941101</creationdate><title>Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants</title><author>Seldon, H.L. ; Dahm, M.C. ; Clark, G.M. ; Crowe, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-60d25e7d6570924545e9f6642be8a4e61f9fbe03b2fc433cf7c048f9643abad53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acrylic Resins - adverse effects</topic><topic>Acrylic Resins - chemistry</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Body Fluids - metabolism</topic><topic>Cats</topic><topic>Cells, Cultured</topic><topic>Cochlea - drug effects</topic><topic>Cochlea - pathology</topic><topic>Cochlea - ultrastructure</topic><topic>Cochlear implant</topic><topic>Cochlear Implants</topic><topic>Humans</topic><topic>hydrogel</topic><topic>implant material</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - ultrastructure</topic><topic>Medical sciences</topic><topic>Microelectrodes</topic><topic>Microscopy, Electron, Scanning</topic><topic>Molecular Weight</topic><topic>Orthopedic surgery</topic><topic>Regression Analysis</topic><topic>Silicone Elastomers - adverse effects</topic><topic>Silicone Elastomers - chemistry</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seldon, H.L.</creatorcontrib><creatorcontrib>Dahm, M.C.</creatorcontrib><creatorcontrib>Clark, G.M.</creatorcontrib><creatorcontrib>Crowe, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seldon, H.L.</au><au>Dahm, M.C.</au><au>Clark, G.M.</au><au>Crowe, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>15</volume><issue>14</issue><spage>1161</spage><epage>1169</epage><pages>1161-1169</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>We present a new hygroscopic implant material which consists of high-molecular-weight polyacrylic acid (PAA) as a filler in a Silastic
R matrix. The mixture swells upon immersion in bodily fluids; the degree of swelling depends on the ratio of PAA to Silastic and allows the design of implants that will achieve their final shape and size only after the implantation procedure.
In vivo and
in vitro biocompatibility tests reveal no adverse cellular or tissue responses. In cochlear implant development the material has been experimentally incorporated into intracochlear electrode arrays which curl after insertion, and in bacteriostatic devices for electrode fixation.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7893919</pmid><doi>10.1016/0142-9612(94)90237-2</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 1994-11, Vol.15 (14), p.1161-1169 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16911757 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acrylic Resins - adverse effects Acrylic Resins - chemistry Analysis of Variance Animals Biocompatible Materials - chemistry Biological and medical sciences Body Fluids - metabolism Cats Cells, Cultured Cochlea - drug effects Cochlea - pathology Cochlea - ultrastructure Cochlear implant Cochlear Implants Humans hydrogel implant material Macrophages - cytology Macrophages - drug effects Macrophages - ultrastructure Medical sciences Microelectrodes Microscopy, Electron, Scanning Molecular Weight Orthopedic surgery Regression Analysis Silicone Elastomers - adverse effects Silicone Elastomers - chemistry Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases |
| title | Silastic with polyacrylic acid filler: swelling properties, biocompatibility and potential use in cochlear implants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T04%3A00%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Silastic%20with%20polyacrylic%20acid%20filler:%20swelling%20properties,%20biocompatibility%20and%20potential%20use%20in%20cochlear%20implants&rft.jtitle=Biomaterials&rft.au=Seldon,%20H.L.&rft.date=1994-11-01&rft.volume=15&rft.issue=14&rft.spage=1161&rft.epage=1169&rft.pages=1161-1169&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/0142-9612(94)90237-2&rft_dat=%3Cproquest_cross%3E16911757%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16911757&rft_id=info:pmid/7893919&rft_els_id=0142961294902372&rfr_iscdi=true |