AF is associated with self-reported syncope and falls in a general population cohort
syncope is an important, but underestimated clinical problem in older persons. It is often overlooked in clinical practice or mistaken for falls. Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little evidence exists regarding the association between AF, falls and syncope in the...
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Veröffentlicht in: | Age and ageing 2015-07, Vol.44 (4), p.598-603 |
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description | syncope is an important, but underestimated clinical problem in older persons. It is often overlooked in clinical practice or mistaken for falls. Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little evidence exists regarding the association between AF, falls and syncope in the general population.
cross-sectional analyses within a population sample of people aged 50+, taken from The Irish Longitudinal Study on Ageing. Ten-minute electrocardiogram recordings (n = 4,885) were analysed to detect AF. Syncope (self-reported faints or blackouts) and falls in the past year, co-morbidities, health measures and medications were gathered through computer-aided personal interviews. Multivariable logistic regression was performed to study associations between AF, falls and syncope.
mean age was 62 years (range: 50-91), 54% were female. Prevalence of AF was 3%, increasing to 8% in participants aged 75+. Of participants, 5% (n = 223) reported syncope and 20% (n = 972) reported falls. After adjustment for confounders, AF was significantly associated with faints and blackouts (odds ratio (OR) 2.0 [95% confidence interval (CI) 1.0-3.9]). After stratification by age category, we found that this association was strongest and only significant in participants aged 50-64 years (OR 4.4 [1.5-12.6]). Stratified for age group, AF was significantly associated with falls in participants aged 65-74 years (OR 2.0 [1.0-4.1]).
adults aged 50+ with self-reported syncope and adults aged 65-74 years with falls are twice as likely to have AF at physical examination. These associations are independent of stroke, cardiovascular and psychotropic drugs and other confounders. Further longitudinal studies are needed to explore this association and potential causality further. |
doi_str_mv | 10.1093/ageing/afv017 |
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cross-sectional analyses within a population sample of people aged 50+, taken from The Irish Longitudinal Study on Ageing. Ten-minute electrocardiogram recordings (n = 4,885) were analysed to detect AF. Syncope (self-reported faints or blackouts) and falls in the past year, co-morbidities, health measures and medications were gathered through computer-aided personal interviews. Multivariable logistic regression was performed to study associations between AF, falls and syncope.
mean age was 62 years (range: 50-91), 54% were female. Prevalence of AF was 3%, increasing to 8% in participants aged 75+. Of participants, 5% (n = 223) reported syncope and 20% (n = 972) reported falls. After adjustment for confounders, AF was significantly associated with faints and blackouts (odds ratio (OR) 2.0 [95% confidence interval (CI) 1.0-3.9]). After stratification by age category, we found that this association was strongest and only significant in participants aged 50-64 years (OR 4.4 [1.5-12.6]). Stratified for age group, AF was significantly associated with falls in participants aged 65-74 years (OR 2.0 [1.0-4.1]).
adults aged 50+ with self-reported syncope and adults aged 65-74 years with falls are twice as likely to have AF at physical examination. These associations are independent of stroke, cardiovascular and psychotropic drugs and other confounders. Further longitudinal studies are needed to explore this association and potential causality further.</description><identifier>ISSN: 0002-0729</identifier><identifier>EISSN: 1468-2834</identifier><identifier>DOI: 10.1093/ageing/afv017</identifier><identifier>PMID: 25712516</identifier><identifier>CODEN: AANGAH</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Accidental Falls - statistics & numerical data ; Aged ; Aged, 80 and over ; Arrhythmia ; Atrial Fibrillation - complications ; Atrial Fibrillation - epidemiology ; Atrial Fibrillation - physiopathology ; Cardiac arrhythmia ; Care and treatment ; Cross-Sectional Studies ; Elderly ; Electrocardiogram ; Electrocardiography ; Fainting ; Falls ; Female ; Health aspects ; Humans ; Ireland - epidemiology ; Male ; Middle Aged ; Older people ; Population Surveillance ; Prevalence ; Prospective Studies ; Risk Assessment - methods ; Risk Factors ; Self Report ; Syncope - epidemiology ; Syncope - etiology</subject><ispartof>Age and ageing, 2015-07, Vol.44 (4), p.598-603</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</rights><rights>Copyright Oxford Publishing Limited(England) Jul 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-c107421e2716774d02facc702ca5648f471d8b385eeab7e199680e82ff50efaa3</citedby><cites>FETCH-LOGICAL-c398t-c107421e2716774d02facc702ca5648f471d8b385eeab7e199680e82ff50efaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,30999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25712516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jansen, Sofie</creatorcontrib><creatorcontrib>Frewen, John</creatorcontrib><creatorcontrib>Finucane, Ciaran</creatorcontrib><creatorcontrib>de Rooij, Sophia E</creatorcontrib><creatorcontrib>van der Velde, Nathalie</creatorcontrib><creatorcontrib>Kenny, Rose Anne</creatorcontrib><title>AF is associated with self-reported syncope and falls in a general population cohort</title><title>Age and ageing</title><addtitle>Age Ageing</addtitle><description>syncope is an important, but underestimated clinical problem in older persons. It is often overlooked in clinical practice or mistaken for falls. Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little evidence exists regarding the association between AF, falls and syncope in the general population.
cross-sectional analyses within a population sample of people aged 50+, taken from The Irish Longitudinal Study on Ageing. Ten-minute electrocardiogram recordings (n = 4,885) were analysed to detect AF. Syncope (self-reported faints or blackouts) and falls in the past year, co-morbidities, health measures and medications were gathered through computer-aided personal interviews. Multivariable logistic regression was performed to study associations between AF, falls and syncope.
mean age was 62 years (range: 50-91), 54% were female. Prevalence of AF was 3%, increasing to 8% in participants aged 75+. Of participants, 5% (n = 223) reported syncope and 20% (n = 972) reported falls. After adjustment for confounders, AF was significantly associated with faints and blackouts (odds ratio (OR) 2.0 [95% confidence interval (CI) 1.0-3.9]). After stratification by age category, we found that this association was strongest and only significant in participants aged 50-64 years (OR 4.4 [1.5-12.6]). Stratified for age group, AF was significantly associated with falls in participants aged 65-74 years (OR 2.0 [1.0-4.1]).
adults aged 50+ with self-reported syncope and adults aged 65-74 years with falls are twice as likely to have AF at physical examination. These associations are independent of stroke, cardiovascular and psychotropic drugs and other confounders. Further longitudinal studies are needed to explore this association and potential causality further.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arrhythmia</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Cardiac arrhythmia</subject><subject>Care and treatment</subject><subject>Cross-Sectional Studies</subject><subject>Elderly</subject><subject>Electrocardiogram</subject><subject>Electrocardiography</subject><subject>Fainting</subject><subject>Falls</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Ireland - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Population Surveillance</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>Syncope - epidemiology</subject><subject>Syncope - etiology</subject><issn>0002-0729</issn><issn>1468-2834</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNpdkc1rGzEQxUVpaRynx16DoJdctpa0H9o9GlMnhUAuyVmMtaONgixtpN22_u8jY6eFnoYZfjO8N4-Qr5x956wrVzCg9cMKzC_G5Qey4FXTFqItq49kwRgTBZOiuyCXKb3kltdcfCYXopZc1LxZkMf1ltpEIaWgLUzY0992eqYJnSkijiEeR-ngdRiRgu-pAecStZ4CHdBjBEfHMM4OJhs81eE5r1yRTxlL-OVcl-Rp--Nxc1fcP9z-3KzvC1127VRozmQlOArJGymrngkDWksmNNRN1ZpK8r7dlW2NCDuJvOualmErjKkZGoBySW5Od8cYXmdMk9rbpNE58BjmpHjT8Wy5kV1Gv_2HvoQ5-qzuSFX5RzUrM1WcqAEcKptd-wn_TDo4hwOqLH7zoNZVyfJGzbp_vI4hpYhGjdHuIR4UZ-oYjzrFo07xZP76rGLe7bH_S7_nUb4BsA-LUA</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Jansen, Sofie</creator><creator>Frewen, John</creator><creator>Finucane, Ciaran</creator><creator>de Rooij, Sophia E</creator><creator>van der Velde, Nathalie</creator><creator>Kenny, Rose Anne</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201507</creationdate><title>AF is associated with self-reported syncope and falls in a general population cohort</title><author>Jansen, Sofie ; Frewen, John ; Finucane, Ciaran ; de Rooij, Sophia E ; van der Velde, Nathalie ; Kenny, Rose Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-c107421e2716774d02facc702ca5648f471d8b385eeab7e199680e82ff50efaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arrhythmia</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Cardiac arrhythmia</topic><topic>Care and treatment</topic><topic>Cross-Sectional Studies</topic><topic>Elderly</topic><topic>Electrocardiogram</topic><topic>Electrocardiography</topic><topic>Fainting</topic><topic>Falls</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Ireland - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Population Surveillance</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Risk Factors</topic><topic>Self Report</topic><topic>Syncope - epidemiology</topic><topic>Syncope - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jansen, Sofie</creatorcontrib><creatorcontrib>Frewen, John</creatorcontrib><creatorcontrib>Finucane, Ciaran</creatorcontrib><creatorcontrib>de Rooij, Sophia E</creatorcontrib><creatorcontrib>van der Velde, Nathalie</creatorcontrib><creatorcontrib>Kenny, Rose Anne</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Age and ageing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jansen, Sofie</au><au>Frewen, John</au><au>Finucane, Ciaran</au><au>de Rooij, Sophia E</au><au>van der Velde, Nathalie</au><au>Kenny, Rose Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>AF is associated with self-reported syncope and falls in a general population cohort</atitle><jtitle>Age and ageing</jtitle><addtitle>Age Ageing</addtitle><date>2015-07</date><risdate>2015</risdate><volume>44</volume><issue>4</issue><spage>598</spage><epage>603</epage><pages>598-603</pages><issn>0002-0729</issn><eissn>1468-2834</eissn><coden>AANGAH</coden><abstract>syncope is an important, but underestimated clinical problem in older persons. It is often overlooked in clinical practice or mistaken for falls. Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little evidence exists regarding the association between AF, falls and syncope in the general population.
cross-sectional analyses within a population sample of people aged 50+, taken from The Irish Longitudinal Study on Ageing. Ten-minute electrocardiogram recordings (n = 4,885) were analysed to detect AF. Syncope (self-reported faints or blackouts) and falls in the past year, co-morbidities, health measures and medications were gathered through computer-aided personal interviews. Multivariable logistic regression was performed to study associations between AF, falls and syncope.
mean age was 62 years (range: 50-91), 54% were female. Prevalence of AF was 3%, increasing to 8% in participants aged 75+. Of participants, 5% (n = 223) reported syncope and 20% (n = 972) reported falls. After adjustment for confounders, AF was significantly associated with faints and blackouts (odds ratio (OR) 2.0 [95% confidence interval (CI) 1.0-3.9]). After stratification by age category, we found that this association was strongest and only significant in participants aged 50-64 years (OR 4.4 [1.5-12.6]). Stratified for age group, AF was significantly associated with falls in participants aged 65-74 years (OR 2.0 [1.0-4.1]).
adults aged 50+ with self-reported syncope and adults aged 65-74 years with falls are twice as likely to have AF at physical examination. These associations are independent of stroke, cardiovascular and psychotropic drugs and other confounders. Further longitudinal studies are needed to explore this association and potential causality further.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25712516</pmid><doi>10.1093/ageing/afv017</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Accidental Falls - statistics & numerical data Aged Aged, 80 and over Arrhythmia Atrial Fibrillation - complications Atrial Fibrillation - epidemiology Atrial Fibrillation - physiopathology Cardiac arrhythmia Care and treatment Cross-Sectional Studies Elderly Electrocardiogram Electrocardiography Fainting Falls Female Health aspects Humans Ireland - epidemiology Male Middle Aged Older people Population Surveillance Prevalence Prospective Studies Risk Assessment - methods Risk Factors Self Report Syncope - epidemiology Syncope - etiology |
title | AF is associated with self-reported syncope and falls in a general population cohort |
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