Impact of genetic variation in the SMIM1 gene on Vel expression levels

BACKGROUND Serologic determination of the Vel– phenotype is challenging due to variable Vel expression levels. In this study we investigated the genetic basis for weak Vel expression levels and developed a high‐throughput genotyping assay to detect Vel– donors. STUDY DESIGN AND METHODS In 548 random...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2015-06, Vol.55 (6pt2), p.1457-1466
Hauptverfasser:	Haer-Wigman, Lonneke, Stegmann, Tamara C., Solati, Shabnam, Ait Soussan, Aïcha, Beckers, Erik, van der Harst, Pim, van Hulst-Sundermeijer, Marga, Ligthart, Peter, van Rhenen, Dick, Schepers, Hein, de Haas, Masja, van der Schoot, C. Ellen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Blood Donors - statistics & numerical data Blood Group Antigens - genetics Continental Population Groups - genetics Genetic Variation Genotype HEK293 Cells Humans Membrane Proteins - genetics Phenotype Polymorphism, Single Nucleotide Sequence Analysis, DNA Sequence Deletion Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!