Sustained Modeling‐Based Bone Formation During Adulthood in Cynomolgus Monkeys May Contribute to Continuous BMD Gains With Denosumab

ABSTRACT Denosumab (DMAb) administration to postmenopausal women with osteoporosis is associated with continued bone mineral density (BMD) increases and low fracture incidence through 8 years, despite persistently reduced bone turnover markers and limited fluorochrome labeling in iliac crest bone bi...

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Veröffentlicht in:	Journal of bone and mineral research 2015-07, Vol.30 (7), p.1280-1289
Hauptverfasser:	Ominsky, Michael S, Libanati, Cesar, Niu, Qing‐Tian, Boyce, Rogely W, Kostenuik, Paul J, Wagman, Rachel B, Baron, Roland, Dempster, David W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals ANTIRESORPTIVES Bone Density - drug effects BONE HISTOMORPHOMETRY BONE MODELING AND REMODELING Bone Remodeling - drug effects Denosumab - pharmacology Female Femur Neck - drug effects Femur Neck - physiology Fluorescent Dyes - metabolism Macaca fascicularis Osteogenesis - drug effects OSTEOPOROSIS Ovariectomy PRECLINICAL STUDIES Staining and Labeling
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