Anti-angiogenic activity of thienopyridine derivative LCB03-0110 by targeting VEGFR-2 and JAK/STAT3 Signalling

Vascular endothelial growth factor receptor‐2 (VEGFR‐2) and Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signalling are important for tumor angiogenesis and metastasis. In this study, we identified (3‐(2‐(3‐(morpholinomethyl)phenyl)thieno[3,2‐b]pyridin‐7‐ylamino)phen...

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Veröffentlicht in:	Experimental dermatology 2015-07, Vol.24 (7), p.503-509
Hauptverfasser:	Kim, Byung-Hak, Lee, Yoonji, Yoo, Hyun, Cui, Minghua, Lee, Sungwoon, Kim, Sun Young, Cho, Jong Un, Lee, Hyangsook, Yang, Beom-Seok, Kwon, Young-Guen, Choi, Sun, Kim, Tae-Yoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Aminopyridines - pharmacology angiogenesis Angiogenesis Inhibitors - pharmacology Animals Binding Sites Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - physiology Human Umbilical Vein Endothelial Cells Humans JAK/STAT3 Janus Kinases - antagonists & inhibitors LCB03-0110 Lung Neoplasms - prevention & control Lung Neoplasms - secondary Male Mice Mice, Hairless Mice, Inbred BALB C Mice, Nude Models, Molecular Protein Structure, Secondary Rats Receptor, TIE-2 - antagonists & inhibitors Signal Transduction - drug effects src-Family Kinases - antagonists & inhibitors STAT3 Transcription Factor - antagonists & inhibitors Thiophenes - pharmacology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - chemistry VEGFR-2 Xenograft Model Antitumor Assays
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