ASXL1 mutations are frequent and prognostically detrimental in CSF3R‐mutated chronic neutrophilic leukemia

Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients with CSF3R‐mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 (38%) harbored an ASXL1 and/or SETBP1 mu...

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Veröffentlicht in:	American journal of hematology 2015-07, Vol.90 (7), p.653-656
Hauptverfasser:	Elliott, Michelle A., Pardanani, Animesh, Hanson, Curtis A., Lasho, Terra L., Finke, Christy M., Belachew, Alem A., Tefferi, Ayalew
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Carrier Proteins - genetics Disease Progression Female Gene Expression Hematology Humans Leukemia, Myelomonocytic, Chronic - diagnosis Leukemia, Myelomonocytic, Chronic - drug therapy Leukemia, Myelomonocytic, Chronic - genetics Leukemia, Myelomonocytic, Chronic - mortality Leukemia, Neutrophilic, Chronic - diagnosis Leukemia, Neutrophilic, Chronic - drug therapy Leukemia, Neutrophilic, Chronic - genetics Leukemia, Neutrophilic, Chronic - mortality Male Middle Aged Mutation Nuclear Proteins - genetics Prognosis Receptors, Colony-Stimulating Factor - genetics Repressor Proteins - genetics Retrospective Studies Risk Factors Survival Analysis Thrombocytopenia - physiopathology
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