Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specific γ-Glutamyltranspeptidase

γ‐Glutamyltranspeptidase (GGT) is a tumor biomarker that selectively catalyzes the cleavage of glutamate overexpressed on the plasma membrane of tumor cells. Here, we developed two novel fluorescent in situ targeting (FIST) probes that specifically target GGT in tumor cells, which comprise 1) a GGT‐...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-06, Vol.54 (25), p.7349-7353
Hauptverfasser:	Wang, Feiyi, Zhu, Ying, Zhou, Li, Pan, Liang, Cui, Zhifen, Fei, Qiang, Luo, Sihang, Pan, Dun, Huang, Qing, Wang, Rui, Zhao, Chunchang, Tian, He, Fan, Chunhai
Format:	Artikel
Sprache:	eng
Schlagworte:	aromatic hydrocarbon transfer Boron Compounds - chemistry Boron Compounds - metabolism Cell Line, Tumor Enzyme Assays - methods enzymes Female fluorescence Fluorescent Dyes - chemistry Fluorescent Dyes - metabolism gamma-Glutamyltransferase - analysis gamma-Glutamyltransferase - metabolism Human Umbilical Vein Endothelial Cells Humans Microscopy, Confocal - methods Optical Imaging - methods Ovarian Neoplasms - diagnosis Ovarian Neoplasms - enzymology Ovary - enzymology photophysics Porphobilinogen - analogs & derivatives Porphobilinogen - chemistry Porphobilinogen - metabolism tumor cells
Online-Zugang:	Volltext
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