Calcium and protein kinase C regulation of the glucocorticoid receptor in mouse corticotrope tumor cells

The effect of increasing intracellular free calcium and activating protein kinase C on glucocorticoid receptor (GR) expression was investigated in AtT-20 cells, a mouse corticotrope tumor cell line. Treatment of AtT-20 cells with the calcium ionophore A23187 induced a rapid time- and dose-dependent...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1994-03, Vol.48 (4), p.337-345
1. Verfasser:	Sheppard, Karen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Animals Biological and medical sciences Calcimycin - pharmacology Calcium - pharmacology Cell receptors Cell structures and functions Cycloheximide - pharmacology Dexamethasone - metabolism Enzyme Activation - drug effects Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Kinetics Mice Molecular and cellular biology Pituitary Neoplasms - metabolism Protein Kinase C - metabolism Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism RNA, Messenger Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
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