Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes
Background: In neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin Z,E -photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference...
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| Veröffentlicht in: | Pediatric research 2015-07, Vol.78 (1), p.56-62 |
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| creator | Mreihil, Khalaf Madsen, Poul Nakstad, Britt Benth, Jūratė Šaltytė Ebbesen, Finn Hansen, Thor Willy Ruud |
| description | Background:
In neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin
Z,E
-photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference, compared to double fluorescent lights, and a single unit of photodiodes.
Methods:
Neonates (
N
= 42; birth weight: 1,200–4,690 g; gestational age: 28–42 wk) were studied during phototherapy. Infants were randomized to: (i) single, or (ii) double fluorescent phototherapy; or (iii) single unit photodiodes. Irradiance was measured. Serum bilirubin (by cooximetry) and
Z,E
bilirubin (by high-pressure liquid chromatography) were measured at 0,15, 30, 60, 120, and 240 min after the start of phototherapy. Data were analyzed with a linear mixed model.
Results:
There was a highly significant increase of
Z,E
-bilirubin over time (
P
< 0.0001), starting at 15 min. Photoisomers reached ~25% of total bilirubin concentration after 4 h. However, there were no significant differences between the three randomized groups in spite of significantly higher irradiance using double fluorescent lights vs. single fluorescent or photodiodes.
Conclusion:
Formation of bilirubin photoisomers is rapid, and occurs early during intensive phototherapy for neonatal jaundice. The rate and level of photoisomerization was not influenced by irradiance and light source. |
| doi_str_mv | 10.1038/pr.2015.61 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1690217843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1690217843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-5f9b501c528319dd84b7d28fea27af913961ebcd489ae0f13ea7f38d54f421c73</originalsourceid><addsrcrecordid>eNptkMFu1DAQhi0EokvhwgMgHxEoiye2E5sbqkpBqsQFzpETj6lXThzsuFJfgmfGu1s4cfJY882nmZ-Q18D2wLj6sKZ9y0DuO3hCdiA5a5gQ_VOyY4xDw7VWF-RFzgfGQEglnpOLVvZagOp25Pe1SeGBuphms_m40Ojo6INPZfQL9TnOmDK1JfnlJ13v4ha3O0xmPY3QBeNiNhPowZTF-gk_UnQOpy0fPbnOBKT3eU9tLGMtXSgxYZ5w2Wgw85pPzZPW-mgxvyTPnAkZXz2-l-TH5-vvV1-a2283X68-3TYTl3prpNOjZDDJVnHQ1iox9rZVDk3bG6eB6w5wnKxQ2iBzwNH0jisrhRMtTD2_JG_P3jXFXwXzNsy-rhWCqSeVPECnWQu9Eryi787olGLOCd2wJj-b9DAAG4751_9wzH_ooMJvHr1lnNH-Q_8GXoH3ZyCvx0gxDYdY0lJv_Z_uD09tkjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1690217843</pqid></control><display><type>article</type><title>Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Mreihil, Khalaf ; Madsen, Poul ; Nakstad, Britt ; Benth, Jūratė Šaltytė ; Ebbesen, Finn ; Hansen, Thor Willy Ruud</creator><creatorcontrib>Mreihil, Khalaf ; Madsen, Poul ; Nakstad, Britt ; Benth, Jūratė Šaltytė ; Ebbesen, Finn ; Hansen, Thor Willy Ruud</creatorcontrib><description>Background:
In neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin
Z,E
-photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference, compared to double fluorescent lights, and a single unit of photodiodes.
Methods:
Neonates (
N
= 42; birth weight: 1,200–4,690 g; gestational age: 28–42 wk) were studied during phototherapy. Infants were randomized to: (i) single, or (ii) double fluorescent phototherapy; or (iii) single unit photodiodes. Irradiance was measured. Serum bilirubin (by cooximetry) and
Z,E
bilirubin (by high-pressure liquid chromatography) were measured at 0,15, 30, 60, 120, and 240 min after the start of phototherapy. Data were analyzed with a linear mixed model.
Results:
There was a highly significant increase of
Z,E
-bilirubin over time (
P
< 0.0001), starting at 15 min. Photoisomers reached ~25% of total bilirubin concentration after 4 h. However, there were no significant differences between the three randomized groups in spite of significantly higher irradiance using double fluorescent lights vs. single fluorescent or photodiodes.
Conclusion:
Formation of bilirubin photoisomers is rapid, and occurs early during intensive phototherapy for neonatal jaundice. The rate and level of photoisomerization was not influenced by irradiance and light source.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2015.61</identifier><identifier>PMID: 25794186</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/3187 ; Bilirubin - blood ; Bilirubin - chemistry ; Birth Weight ; Chromatography, High Pressure Liquid ; Equipment Design ; Gestational Age ; Humans ; Infant, Newborn ; Jaundice, Neonatal - blood ; Jaundice, Neonatal - therapy ; Light ; Linear Models ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Phototherapy - instrumentation ; Phototherapy - methods ; translational-investigation</subject><ispartof>Pediatric research, 2015-07, Vol.78 (1), p.56-62</ispartof><rights>International Pediatric Research Foundation, Inc. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-5f9b501c528319dd84b7d28fea27af913961ebcd489ae0f13ea7f38d54f421c73</citedby><cites>FETCH-LOGICAL-c359t-5f9b501c528319dd84b7d28fea27af913961ebcd489ae0f13ea7f38d54f421c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25794186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mreihil, Khalaf</creatorcontrib><creatorcontrib>Madsen, Poul</creatorcontrib><creatorcontrib>Nakstad, Britt</creatorcontrib><creatorcontrib>Benth, Jūratė Šaltytė</creatorcontrib><creatorcontrib>Ebbesen, Finn</creatorcontrib><creatorcontrib>Hansen, Thor Willy Ruud</creatorcontrib><title>Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background:
In neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin
Z,E
-photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference, compared to double fluorescent lights, and a single unit of photodiodes.
Methods:
Neonates (
N
= 42; birth weight: 1,200–4,690 g; gestational age: 28–42 wk) were studied during phototherapy. Infants were randomized to: (i) single, or (ii) double fluorescent phototherapy; or (iii) single unit photodiodes. Irradiance was measured. Serum bilirubin (by cooximetry) and
Z,E
bilirubin (by high-pressure liquid chromatography) were measured at 0,15, 30, 60, 120, and 240 min after the start of phototherapy. Data were analyzed with a linear mixed model.
Results:
There was a highly significant increase of
Z,E
-bilirubin over time (
P
< 0.0001), starting at 15 min. Photoisomers reached ~25% of total bilirubin concentration after 4 h. However, there were no significant differences between the three randomized groups in spite of significantly higher irradiance using double fluorescent lights vs. single fluorescent or photodiodes.
Conclusion:
Formation of bilirubin photoisomers is rapid, and occurs early during intensive phototherapy for neonatal jaundice. The rate and level of photoisomerization was not influenced by irradiance and light source.</description><subject>692/308/3187</subject><subject>Bilirubin - blood</subject><subject>Bilirubin - chemistry</subject><subject>Birth Weight</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Equipment Design</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Jaundice, Neonatal - blood</subject><subject>Jaundice, Neonatal - therapy</subject><subject>Light</subject><subject>Linear Models</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Phototherapy - instrumentation</subject><subject>Phototherapy - methods</subject><subject>translational-investigation</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFu1DAQhi0EokvhwgMgHxEoiye2E5sbqkpBqsQFzpETj6lXThzsuFJfgmfGu1s4cfJY882nmZ-Q18D2wLj6sKZ9y0DuO3hCdiA5a5gQ_VOyY4xDw7VWF-RFzgfGQEglnpOLVvZagOp25Pe1SeGBuphms_m40Ojo6INPZfQL9TnOmDK1JfnlJ13v4ha3O0xmPY3QBeNiNhPowZTF-gk_UnQOpy0fPbnOBKT3eU9tLGMtXSgxYZ5w2Wgw85pPzZPW-mgxvyTPnAkZXz2-l-TH5-vvV1-a2283X68-3TYTl3prpNOjZDDJVnHQ1iox9rZVDk3bG6eB6w5wnKxQ2iBzwNH0jisrhRMtTD2_JG_P3jXFXwXzNsy-rhWCqSeVPECnWQu9Eryi787olGLOCd2wJj-b9DAAG4751_9wzH_ooMJvHr1lnNH-Q_8GXoH3ZyCvx0gxDYdY0lJv_Z_uD09tkjw</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Mreihil, Khalaf</creator><creator>Madsen, Poul</creator><creator>Nakstad, Britt</creator><creator>Benth, Jūratė Šaltytė</creator><creator>Ebbesen, Finn</creator><creator>Hansen, Thor Willy Ruud</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes</title><author>Mreihil, Khalaf ; Madsen, Poul ; Nakstad, Britt ; Benth, Jūratė Šaltytė ; Ebbesen, Finn ; Hansen, Thor Willy Ruud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-5f9b501c528319dd84b7d28fea27af913961ebcd489ae0f13ea7f38d54f421c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>692/308/3187</topic><topic>Bilirubin - blood</topic><topic>Bilirubin - chemistry</topic><topic>Birth Weight</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Equipment Design</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Jaundice, Neonatal - blood</topic><topic>Jaundice, Neonatal - therapy</topic><topic>Light</topic><topic>Linear Models</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Phototherapy - instrumentation</topic><topic>Phototherapy - methods</topic><topic>translational-investigation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mreihil, Khalaf</creatorcontrib><creatorcontrib>Madsen, Poul</creatorcontrib><creatorcontrib>Nakstad, Britt</creatorcontrib><creatorcontrib>Benth, Jūratė Šaltytė</creatorcontrib><creatorcontrib>Ebbesen, Finn</creatorcontrib><creatorcontrib>Hansen, Thor Willy Ruud</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mreihil, Khalaf</au><au>Madsen, Poul</au><au>Nakstad, Britt</au><au>Benth, Jūratė Šaltytė</au><au>Ebbesen, Finn</au><au>Hansen, Thor Willy Ruud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>78</volume><issue>1</issue><spage>56</spage><epage>62</epage><pages>56-62</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background:
In neonatal jaundice, phototherapy converts bilirubin to more polar photoisomers which can be excreted without conjugation. We measured changes in the concentration of bilirubin
Z,E
-photoisomer during the first 4 h of intensive phototherapy using single fluorescent lights as a reference, compared to double fluorescent lights, and a single unit of photodiodes.
Methods:
Neonates (
N
= 42; birth weight: 1,200–4,690 g; gestational age: 28–42 wk) were studied during phototherapy. Infants were randomized to: (i) single, or (ii) double fluorescent phototherapy; or (iii) single unit photodiodes. Irradiance was measured. Serum bilirubin (by cooximetry) and
Z,E
bilirubin (by high-pressure liquid chromatography) were measured at 0,15, 30, 60, 120, and 240 min after the start of phototherapy. Data were analyzed with a linear mixed model.
Results:
There was a highly significant increase of
Z,E
-bilirubin over time (
P
< 0.0001), starting at 15 min. Photoisomers reached ~25% of total bilirubin concentration after 4 h. However, there were no significant differences between the three randomized groups in spite of significantly higher irradiance using double fluorescent lights vs. single fluorescent or photodiodes.
Conclusion:
Formation of bilirubin photoisomers is rapid, and occurs early during intensive phototherapy for neonatal jaundice. The rate and level of photoisomerization was not influenced by irradiance and light source.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25794186</pmid><doi>10.1038/pr.2015.61</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/308/3187 Bilirubin - blood Bilirubin - chemistry Birth Weight Chromatography, High Pressure Liquid Equipment Design Gestational Age Humans Infant, Newborn Jaundice, Neonatal - blood Jaundice, Neonatal - therapy Light Linear Models Medicine & Public Health Pediatric Surgery Pediatrics Phototherapy - instrumentation Phototherapy - methods translational-investigation |
| title | Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes |
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