Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1

Summary In the past decade, studies have shown how instrumental programmed cell death (PCD) can be in innate and adaptive immune responses. PCD can be a means to maintain homeostasis, prevent or promote microbial pathogenesis, and drive autoimmune disease and inflammation. The molecular machinery re...

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Veröffentlicht in:	Immunological reviews 2015-07, Vol.266 (1), p.145-160
Hauptverfasser:	Justus, Scott J., Ting, Adrian T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspase-8 CYLD Humans necroptosis Necrosis Receptor-Interacting Protein Serine-Threonine Kinases - metabolism RIPK1 RIPK3 Signal Transduction Tumor Necrosis Factor-alpha - metabolism ubiquitin Ubiquitin - metabolism
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