Management of generalised convulsive status epilepticus (SE): A prospective randomised controlled study of combined treatment with intravenous lorazepam with either phenytoin, sodium valproate or levetiracetam – Pilot study

Highlights • 150 patients: randomised to phenytoin (50), valproate (50) and levetiracetam (50). • Phenytoin group: seizures were controlled in 68% with lorazepam + phenytoin. • Valproate group: seizures were controlled in 68% with lorazepam + valproate. • Levetiracetam group: seizures were controlle...

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Veröffentlicht in:	Epilepsy research 2015-08, Vol.114, p.52-58
Hauptverfasser:	Mundlamuri, R.C, Sinha, S, Subbakrishna, D.K, Prathyusha, P.V, Nagappa, M, Bindu, P.S, Taly, A.B, Umamaheswara Rao, G.S, Satishchandra, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Drug Therapy, Combination Efficacy of AEDs Electroencephalography Epilepsy, Generalized - drug therapy Epilepsy, Generalized - physiopathology Female Follow-Up Studies GCSE Humans Injections, Intravenous Levetiracetam Lorazepam - adverse effects Lorazepam - therapeutic use Male Middle Aged Neurology Phenytoin Phenytoin - adverse effects Phenytoin - therapeutic use Pilot Projects Piracetam - adverse effects Piracetam - analogs & derivatives Piracetam - therapeutic use Prognosis Prospective Studies Status epilepticus Status Epilepticus - drug therapy Treatment Outcome Valproate Valproic Acid - adverse effects Valproic Acid - therapeutic use Young Adult
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Zusammenfassung:	Highlights • 150 patients: randomised to phenytoin (50), valproate (50) and levetiracetam (50). • Phenytoin group: seizures were controlled in 68% with lorazepam + phenytoin. • Valproate group: seizures were controlled in 68% with lorazepam + valproate. • Levetiracetam group: seizures were controlled in 78% with lorazepam + levetiracetam. • Phenytoin, valproate, and levetiracetam are safe and equally efficacious.
ISSN:	0920-1211 1872-6844
DOI:	10.1016/j.eplepsyres.2015.04.013