Orexin A regulates plasma insulin and leptin levels in a time-dependent manner following a glucose load in mice

Aims/hypothesis Orexin A (OXA) is a neuropeptide implicated in the regulation of arousal status and energy metabolism. Orexin receptors are expressed not only in the central nervous system but also in the pancreas and adipose tissue. However, little is known about the physiological function of orexi...

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Veröffentlicht in:	Diabetologia 2015-07, Vol.58 (7), p.1542-1550
Hauptverfasser:	Park, Jae-Hyung, Shim, Hae-Min, Na, Ann-Yae, Bae, Jae-Hoon, Im, Seung-Soon, Song, Dae-Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Calcium - metabolism Diabetes Diabetes Mellitus, Type 2 - metabolism Diet, High-Fat Glucagon Glucagon - blood Glucose Glucose - pharmacology Glucose Tolerance Test Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - physiology Human Physiology Insulin - blood Insulin - metabolism Insulin resistance Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Internal Medicine Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinases Leptin - blood Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Nervous system Obesity Orexin Receptors - drug effects Orexins - pharmacology Pancreas Plasma Proteins
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