Novel encoding methods for DNA-templated chemical libraries
•Encoding strategy has been a major research focus in DNA-encoded library.•This review focuses encoding strategies for DNA-templated libraries.•Three major types of encoding strategies are discussed in details with examples.•This review also discusses encoding strategy in DNA-encoded polymer librari...
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| Veröffentlicht in: | Current opinion in chemical biology 2015-06, Vol.26, p.25-33 |
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| container_title | Current opinion in chemical biology |
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| creator | Li, Gang Zheng, Wenlu Liu, Ying Li, Xiaoyu |
| description | •Encoding strategy has been a major research focus in DNA-encoded library.•This review focuses encoding strategies for DNA-templated libraries.•Three major types of encoding strategies are discussed in details with examples.•This review also discusses encoding strategy in DNA-encoded polymer libraries.
Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries. |
| doi_str_mv | 10.1016/j.cbpa.2015.01.004 |
| format | Article |
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Among various types of DNA-encoded chemical libraries, DNA-templated library takes advantage of the sequence-specificity of DNA hybridization, enabling not only highly effective DNA-templated chemical reactions, but also high fidelity in library encoding. This brief review summarizes recent advances that have been made on the encoding strategies for DNA-templated libraries, and it also highlights their respective advantages and limitations for the preparation of DNA-encoded libraries.</description><identifier>ISSN: 1367-5931</identifier><identifier>EISSN: 1879-0402</identifier><identifier>DOI: 10.1016/j.cbpa.2015.01.004</identifier><identifier>PMID: 25635927</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Binding Sites ; Drug Discovery ; Gene Expression ; Gene Library ; Molecular Probes - chemistry ; Nucleic Acid Hybridization ; Peptide Library ; Peptide Nucleic Acids - chemical synthesis ; Peptide Nucleic Acids - chemistry ; Small Molecule Libraries - chemical synthesis ; Small Molecule Libraries - chemistry</subject><ispartof>Current opinion in chemical biology, 2015-06, Vol.26, p.25-33</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-2be0c80a3ea89c95d6d2a2fcb07d11e4cbcbc3f7877c395d6174bc6d22778b663</citedby><cites>FETCH-LOGICAL-c356t-2be0c80a3ea89c95d6d2a2fcb07d11e4cbcbc3f7877c395d6174bc6d22778b663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2015.01.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25635927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Gang</creatorcontrib><creatorcontrib>Zheng, Wenlu</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Li, Xiaoyu</creatorcontrib><title>Novel encoding methods for DNA-templated chemical libraries</title><title>Current opinion in chemical biology</title><addtitle>Curr Opin Chem Biol</addtitle><description>•Encoding strategy has been a major research focus in DNA-encoded library.•This review focuses encoding strategies for DNA-templated libraries.•Three major types of encoding strategies are discussed in details with examples.•This review also discusses encoding strategy in DNA-encoded polymer libraries.
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| ispartof | Current opinion in chemical biology, 2015-06, Vol.26, p.25-33 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Binding Sites Drug Discovery Gene Expression Gene Library Molecular Probes - chemistry Nucleic Acid Hybridization Peptide Library Peptide Nucleic Acids - chemical synthesis Peptide Nucleic Acids - chemistry Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry |
| title | Novel encoding methods for DNA-templated chemical libraries |
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