Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy
•The analgesic effects of dipyrone, meloxicam or a combination were compared in ovariohysterectomised bitches.•Dipyrone produced superior analgesia than in untreated controls.•Meloxicam produced superior antihyperalgesia than in untreated controls.•The combined use of dipyrone and meloxicam produced...
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| Veröffentlicht in: | The veterinary journal (1997) 2015-07, Vol.205 (1), p.33-37 |
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| container_title | The veterinary journal (1997) |
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| creator | Zanuzzo, Felipe S. Teixeira-Neto, Francisco J. Teixeira, Lívia R. Diniz, Miriely S. Souza, Vivian L. Thomazini, Camila M. Steagall, Paulo V.M. |
| description | •The analgesic effects of dipyrone, meloxicam or a combination were compared in ovariohysterectomised bitches.•Dipyrone produced superior analgesia than in untreated controls.•Meloxicam produced superior antihyperalgesia than in untreated controls.•The combined use of dipyrone and meloxicam produced both beneficial effects.
The analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination were compared in dogs undergoing elective ovariohysterectomy. In a double-blinded, prospective, randomised design, 40 bitches premedicated with intramuscular pethidine (4 mg/kg) and anaesthetised with isoflurane received one of four intravenous treatments (n = 10 per group) before ovariohysterectomy: control (physiological saline), meloxicam (0.2 mg/kg), dipyrone (25 mg/kg) or dipyrone–meloxicam (25 mg/kg and 0.2 mg/kg, respectively). Glasgow composite measure pain scale (GCMPS) and mechanical nociceptive thresholds (MNT) were assessed before anaesthesia and at 1, 2, 3, 4, 6, 8, 12 and 24 h postoperatively. Rescue analgesia (0.5 mg/kg morphine) was administered intramuscularly if the GCMPS was ≥3.
The GCMPS and MNT did not differ among groups. The frequency of rescue analgesia was significantly (P |
| doi_str_mv | 10.1016/j.tvjl.2015.05.004 |
| format | Article |
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The analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination were compared in dogs undergoing elective ovariohysterectomy. In a double-blinded, prospective, randomised design, 40 bitches premedicated with intramuscular pethidine (4 mg/kg) and anaesthetised with isoflurane received one of four intravenous treatments (n = 10 per group) before ovariohysterectomy: control (physiological saline), meloxicam (0.2 mg/kg), dipyrone (25 mg/kg) or dipyrone–meloxicam (25 mg/kg and 0.2 mg/kg, respectively). Glasgow composite measure pain scale (GCMPS) and mechanical nociceptive thresholds (MNT) were assessed before anaesthesia and at 1, 2, 3, 4, 6, 8, 12 and 24 h postoperatively. Rescue analgesia (0.5 mg/kg morphine) was administered intramuscularly if the GCMPS was ≥3.
The GCMPS and MNT did not differ among groups. The frequency of rescue analgesia was significantly (P < 0.05) lower in the dipyrone group (30%) than in controls (50%), but there were no significant differences from the control group in bitches treated with meloxicam (70%) or dipyrone–meloxicam (40%). There was a significant reduction in the total number of rescue treatments in the dypyrone (n = 5) and dipyrone–meloxicam (n = 5) groups when compared with the control (n = 17) and meloxicam (n = 19) groups. Meloxicam and dipyrone–meloxicam significantly reduced the percentage of animals exhibiting severe pain during MNT measurements (30% and 0%, respectively) compared with the control group (50%). Dipyrone produced superior analgesia (reduced morphine consumption), while meloxicam produced better antihyperalgesia (fewer episodes of severe pain) in contrast to controls. When used in tandem, the beneficial effects were combined.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2015.05.004</identifier><identifier>PMID: 26026350</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Anaesthesia ; Analgesia ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Canine ; Dipyrone ; Dipyrone - therapeutic use ; Dogs ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Hyperalgesia - drug therapy ; Hyperalgesia - veterinary ; Hysterectomy - veterinary ; Meloxicam ; Ovariectomy - veterinary ; Pain ; Pain, Postoperative - drug therapy ; Pain, Postoperative - veterinary ; Thiazines - therapeutic use ; Thiazoles - therapeutic use</subject><ispartof>The veterinary journal (1997), 2015-07, Vol.205 (1), p.33-37</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-66ebf1aeb640b14a00ecf8f8ae149f96a2a8206515cfeb221f6586db8a8bcf4c3</citedby><cites>FETCH-LOGICAL-c389t-66ebf1aeb640b14a00ecf8f8ae149f96a2a8206515cfeb221f6586db8a8bcf4c3</cites><orcidid>0000-0002-4396-5860</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1090023315001847$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26026350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zanuzzo, Felipe S.</creatorcontrib><creatorcontrib>Teixeira-Neto, Francisco J.</creatorcontrib><creatorcontrib>Teixeira, Lívia R.</creatorcontrib><creatorcontrib>Diniz, Miriely S.</creatorcontrib><creatorcontrib>Souza, Vivian L.</creatorcontrib><creatorcontrib>Thomazini, Camila M.</creatorcontrib><creatorcontrib>Steagall, Paulo V.M.</creatorcontrib><title>Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>•The analgesic effects of dipyrone, meloxicam or a combination were compared in ovariohysterectomised bitches.•Dipyrone produced superior analgesia than in untreated controls.•Meloxicam produced superior antihyperalgesia than in untreated controls.•The combined use of dipyrone and meloxicam produced both beneficial effects.
The analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination were compared in dogs undergoing elective ovariohysterectomy. In a double-blinded, prospective, randomised design, 40 bitches premedicated with intramuscular pethidine (4 mg/kg) and anaesthetised with isoflurane received one of four intravenous treatments (n = 10 per group) before ovariohysterectomy: control (physiological saline), meloxicam (0.2 mg/kg), dipyrone (25 mg/kg) or dipyrone–meloxicam (25 mg/kg and 0.2 mg/kg, respectively). Glasgow composite measure pain scale (GCMPS) and mechanical nociceptive thresholds (MNT) were assessed before anaesthesia and at 1, 2, 3, 4, 6, 8, 12 and 24 h postoperatively. Rescue analgesia (0.5 mg/kg morphine) was administered intramuscularly if the GCMPS was ≥3.
The GCMPS and MNT did not differ among groups. The frequency of rescue analgesia was significantly (P < 0.05) lower in the dipyrone group (30%) than in controls (50%), but there were no significant differences from the control group in bitches treated with meloxicam (70%) or dipyrone–meloxicam (40%). There was a significant reduction in the total number of rescue treatments in the dypyrone (n = 5) and dipyrone–meloxicam (n = 5) groups when compared with the control (n = 17) and meloxicam (n = 19) groups. Meloxicam and dipyrone–meloxicam significantly reduced the percentage of animals exhibiting severe pain during MNT measurements (30% and 0%, respectively) compared with the control group (50%). Dipyrone produced superior analgesia (reduced morphine consumption), while meloxicam produced better antihyperalgesia (fewer episodes of severe pain) in contrast to controls. When used in tandem, the beneficial effects were combined.</description><subject>Anaesthesia</subject><subject>Analgesia</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Canine</subject><subject>Dipyrone</subject><subject>Dipyrone - therapeutic use</subject><subject>Dogs</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Hyperalgesia - drug therapy</subject><subject>Hyperalgesia - veterinary</subject><subject>Hysterectomy - veterinary</subject><subject>Meloxicam</subject><subject>Ovariectomy - veterinary</subject><subject>Pain</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - veterinary</subject><subject>Thiazines - therapeutic use</subject><subject>Thiazoles - therapeutic use</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFqHDEMNaWlSdP-QA_Fxx4yW9njcWcglxCStBDopT0b2yPvepmxN_bskrnlA3LLH_ZL4mWT9FaQkJCenpAeIZ8ZLBgw-W29mHbrYcGBNQsoBuINOWZNzSvefWdvSw4dVMDr-oh8yHkNAJ0Q_D054hK4rBs4Jg_nQQ9LzN5SHfrik1_NG0wvRXQO7ZRpdLT3mznFgKd0xCHeeatHGhPVr42_94__OjaOxgc9-RioD9T4ya4w023oMS2jD0sadzr5uJrzhKnsiOP8kbxzesj46TmekD9Xl78vflQ3v65_XpzfVLZuu6mSEo1jGo0UYJjQAGhd61qNTHSuk5rrloNsWGMdGs6Zk00re9Pq1lgnbH1Cvh54NynebjFPavTZ4jDogHGbFZMdcOhawQuUH6A2xZwTOrVJftRpVgzUXgW1VnsV1F4FBcVAlKEvz_xbM2L_OvLy9gI4OwCwXLnzmFS2HoPF3u9fofro_8f_BAPsnsQ</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Zanuzzo, Felipe S.</creator><creator>Teixeira-Neto, Francisco J.</creator><creator>Teixeira, Lívia R.</creator><creator>Diniz, Miriely S.</creator><creator>Souza, Vivian L.</creator><creator>Thomazini, Camila M.</creator><creator>Steagall, Paulo V.M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4396-5860</orcidid></search><sort><creationdate>20150701</creationdate><title>Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy</title><author>Zanuzzo, Felipe S. ; Teixeira-Neto, Francisco J. ; Teixeira, Lívia R. ; Diniz, Miriely S. ; Souza, Vivian L. ; Thomazini, Camila M. ; Steagall, Paulo V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-66ebf1aeb640b14a00ecf8f8ae149f96a2a8206515cfeb221f6586db8a8bcf4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Anaesthesia</topic><topic>Analgesia</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Canine</topic><topic>Dipyrone</topic><topic>Dipyrone - therapeutic use</topic><topic>Dogs</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Hyperalgesia - drug therapy</topic><topic>Hyperalgesia - veterinary</topic><topic>Hysterectomy - veterinary</topic><topic>Meloxicam</topic><topic>Ovariectomy - veterinary</topic><topic>Pain</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - veterinary</topic><topic>Thiazines - therapeutic use</topic><topic>Thiazoles - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zanuzzo, Felipe S.</creatorcontrib><creatorcontrib>Teixeira-Neto, Francisco J.</creatorcontrib><creatorcontrib>Teixeira, Lívia R.</creatorcontrib><creatorcontrib>Diniz, Miriely S.</creatorcontrib><creatorcontrib>Souza, Vivian L.</creatorcontrib><creatorcontrib>Thomazini, Camila M.</creatorcontrib><creatorcontrib>Steagall, Paulo V.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanuzzo, Felipe S.</au><au>Teixeira-Neto, Francisco J.</au><au>Teixeira, Lívia R.</au><au>Diniz, Miriely S.</au><au>Souza, Vivian L.</au><au>Thomazini, Camila M.</au><au>Steagall, Paulo V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>205</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>•The analgesic effects of dipyrone, meloxicam or a combination were compared in ovariohysterectomised bitches.•Dipyrone produced superior analgesia than in untreated controls.•Meloxicam produced superior antihyperalgesia than in untreated controls.•The combined use of dipyrone and meloxicam produced both beneficial effects.
The analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination were compared in dogs undergoing elective ovariohysterectomy. In a double-blinded, prospective, randomised design, 40 bitches premedicated with intramuscular pethidine (4 mg/kg) and anaesthetised with isoflurane received one of four intravenous treatments (n = 10 per group) before ovariohysterectomy: control (physiological saline), meloxicam (0.2 mg/kg), dipyrone (25 mg/kg) or dipyrone–meloxicam (25 mg/kg and 0.2 mg/kg, respectively). Glasgow composite measure pain scale (GCMPS) and mechanical nociceptive thresholds (MNT) were assessed before anaesthesia and at 1, 2, 3, 4, 6, 8, 12 and 24 h postoperatively. Rescue analgesia (0.5 mg/kg morphine) was administered intramuscularly if the GCMPS was ≥3.
The GCMPS and MNT did not differ among groups. The frequency of rescue analgesia was significantly (P < 0.05) lower in the dipyrone group (30%) than in controls (50%), but there were no significant differences from the control group in bitches treated with meloxicam (70%) or dipyrone–meloxicam (40%). There was a significant reduction in the total number of rescue treatments in the dypyrone (n = 5) and dipyrone–meloxicam (n = 5) groups when compared with the control (n = 17) and meloxicam (n = 19) groups. Meloxicam and dipyrone–meloxicam significantly reduced the percentage of animals exhibiting severe pain during MNT measurements (30% and 0%, respectively) compared with the control group (50%). Dipyrone produced superior analgesia (reduced morphine consumption), while meloxicam produced better antihyperalgesia (fewer episodes of severe pain) in contrast to controls. When used in tandem, the beneficial effects were combined.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26026350</pmid><doi>10.1016/j.tvjl.2015.05.004</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4396-5860</orcidid></addata></record> |
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| subjects | Anaesthesia Analgesia Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Canine Dipyrone Dipyrone - therapeutic use Dogs Double-Blind Method Drug Therapy, Combination Female Hyperalgesia - drug therapy Hyperalgesia - veterinary Hysterectomy - veterinary Meloxicam Ovariectomy - veterinary Pain Pain, Postoperative - drug therapy Pain, Postoperative - veterinary Thiazines - therapeutic use Thiazoles - therapeutic use |
| title | Analgesic and antihyperalgesic effects of dipyrone, meloxicam or a dipyrone–meloxicam combination in bitches undergoing ovariohysterectomy |
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