Effect of ascorbic acid concentrations on hemodynamics and inflammation following lyophilized plasma transfusion

Compared with lyophilized plasma (LP) buffered with other acids, LP with ascorbic acid (AA) attenuates systemic inflammation and DNA damage in a combat relevant polytrauma swine model. We hypothesize that increasing concentrations of AA in transfused LP will be safe, will be hemodynamically well tol...

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Veröffentlicht in:	The journal of trauma and acute care surgery 2015-07, Vol.79 (1), p.30-38
Hauptverfasser:	McCully, Sean P, Martin, David T, Cook, Mackenzie R, Gordon, Nicole T, McCully, Belinda H, Lee, Tim H, Dean, Rondi K, Rick, Elizabeth A, Moren, Alexis M, Fair, Kelly A, Undurraga, Vicente J, Watson, Kathrine M, Anderson, Nathan W, Schreiber, Martin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid Blood Transfusion Cytokines - blood DNA Damage Female Freeze Drying Hemodynamics Plasma - chemistry Prospective Studies Swine Thrombelastography
Online-Zugang:	Volltext
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