Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 up-regulation-mediated autophagy inhibition

STUDY QUESTION What mechanism is involved in regulating the autophagy of endometrial stromal cells (ESCs), and does it participate in the pathogenesis of endometriosis? SUMMARY ANSWER CXCL12 down-regulates secretory phase ESC autophagy. WHAT IS KNOWN ALREADY mTOR (mammalian target of rapamycin), the...

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Veröffentlicht in:	Human reproduction (Oxford) 2015-07, Vol.30 (7), p.1677-1689
Hauptverfasser:	Mei, Jie, Zhu, Xiao-Yong, Jin, Li-Pin, Duan, Zhong-Liang, Li, Da-Jin, Li, Ming-Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autophagy - physiology Chemokine CXCL12 - secretion Endometriosis - metabolism Endometriosis - physiopathology Endometrium - cytology Endometrium - metabolism Estrogens - metabolism Estrogens - physiology Female Humans Receptors, CXCR4 - metabolism Signal Transduction - physiology Stromal Cells - metabolism Stromal Cells - physiology Up-Regulation
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