Cytogenetic effects of phosphine inhalation by rodents. I: Acute 6-hour exposure of mice

Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. To determine the in vivo cytogenetic effects of inhalation of PH3, male CD‐1 mice were exposed to either 0, 5, 10, or 15 ppm target concentrations of PH3 for 6 hr. Twenty hours aft...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1994, Vol.23 (3), p.186-189
Hauptverfasser:	Kligerman, A. D., Bryant, M. F., Doerr, C. L., Erexson, G. L., Kwanyuen, P., McGee, J. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Biological and medical sciences Cell Cycle - drug effects Cells, Cultured - drug effects Chemical mutagenesis Chromosome Aberrations Dose-Response Relationship, Drug Erythrocytes - drug effects fumigants Insecticides - toxicity lymphocytes Lymphocytes - drug effects Male Medical sciences Mice Mice, Inbred Strains micronuclei Micronucleus Tests Mutagens - administration & dosage Mutagens - toxicity Phosphines - administration & dosage Phosphines - toxicity SCEs Sister Chromatid Exchange Spleen - cytology Spleen - drug effects Time Factors Toxicology
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