No evidence of long-term immunosuppression after high-titer Edmonston-Zagreb measles vaccination in Senegal

In measles vaccine trials in Guinea-Bissau, Senegal, and Haiti, girls who received high-titer Edmonston-Zagreb (EZ; > 10 super(4.7) infectious particles) or Schwarz measles vaccines at 4-6 months of age had a higher mortality than girls receiving standard measles vaccine at 9-10 months of age. We used several different tests with the objectives of finding immunologic differences between the vaccine groups and identifying possible defects that could be corrected through specific interventions (e.g., vitamin A supplementation or nutritional rehabilitation).