Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex
The responses of putative γ-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that γ-aminobutyratergic...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1994-04, Vol.91 (9), p.4009-4013 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4013 |
|---|---|
| container_issue | 9 |
| container_start_page | 4009 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 91 |
| creator | WILSON, F. A. W SCALADHE, S. P. O GOLDMAN-RAKIC, P. S |
| description | The responses of putative γ-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that γ-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with γ-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of γ-aminobutyratergic mechanisms in cognition. |
| doi_str_mv | 10.1073/pnas.91.9.4009 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_16898682</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>2364581</jstor_id><sourcerecordid>2364581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c583t-47d47a0b7c0fe4f25b5c5a65073722d50aa5120dcb7df39e09124b2e2a743e1c3</originalsourceid><addsrcrecordid>eNqFkUGL1DAYhoMo67h69aTQg3hrN0mTpgUv6-DuCsu6oJ7D1zQds7TJmKSr87v8H_4mU2a2jCB4KvR5vjf58iL0kuCCYFGebS2EoiFFUzCMm0doRXBD8oo1-DFaYUxFXjPKnqJnIdzhZPAan6CTmgiS2ArFi8mqaJyFIfu8s9pvTBiz9zr-0Npmt1OEaO519vtXfj4a69op7jxEna-djWCssZvsRk_e2ZCB7bLbREfTpbCHvyaleN372R-ytfNR_3yOnvQwBP3i8D1FXy8-fFlf5defLj-uz69zxesy5kx0TABuhcK9Zj3lLVccKp7WFpR2HANwQnGnWtH1ZaPT4pS1VFMQrNRElafo3T53O7Wj7pS20cMgt96M4HfSgZF_E2u-yY27l6wUhKbxt4dx775POkQ5mqD0MIDVbgpSVKyqCMf_FUlVN3VVz4nFXlTehZCeZbkLwXKuU851yobIRs51poHXxxss-qG_xN8cOAQFQ-_BKhMWjVFeEs6OLjjHP9DlGNlPw5B6iUfn_VNM_NWe34Xo_CLQsmK8JuUfRHHNTQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16898682</pqid></control><display><type>article</type><title>Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>WILSON, F. A. W ; SCALADHE, S. P. O ; GOLDMAN-RAKIC, P. S</creator><creatorcontrib>WILSON, F. A. W ; SCALADHE, S. P. O ; GOLDMAN-RAKIC, P. S</creatorcontrib><description>The responses of putative γ-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that γ-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with γ-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of γ-aminobutyratergic mechanisms in cognition.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.91.9.4009</identifier><identifier>PMID: 8171027</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Action Potentials ; Animals ; Biological and medical sciences ; Cerebral Cortex - physiology ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; gamma-Aminobutyric Acid - physiology ; Histograms ; Interneurons ; Interneurons - physiology ; Macaca mulatta ; Memory - physiology ; Mental stimulation ; Neurobiology ; Neurons ; Neuroscience ; Prefrontal cortex ; Pyramidal cells ; Reed Sternberg cells ; Vertebrates: nervous system and sense organs ; Visual Pathways - physiology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (9), p.4009-4013</ispartof><rights>Copyright 1994 The National Academy of Sciences of the United States of America</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-47d47a0b7c0fe4f25b5c5a65073722d50aa5120dcb7df39e09124b2e2a743e1c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/91/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2364581$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2364581$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27929,27930,53796,53798,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4253154$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8171027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WILSON, F. A. W</creatorcontrib><creatorcontrib>SCALADHE, S. P. O</creatorcontrib><creatorcontrib>GOLDMAN-RAKIC, P. S</creatorcontrib><title>Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The responses of putative γ-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that γ-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with γ-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of γ-aminobutyratergic mechanisms in cognition.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - physiology</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Histograms</subject><subject>Interneurons</subject><subject>Interneurons - physiology</subject><subject>Macaca mulatta</subject><subject>Memory - physiology</subject><subject>Mental stimulation</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neuroscience</subject><subject>Prefrontal cortex</subject><subject>Pyramidal cells</subject><subject>Reed Sternberg cells</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Pathways - physiology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGL1DAYhoMo67h69aTQg3hrN0mTpgUv6-DuCsu6oJ7D1zQds7TJmKSr87v8H_4mU2a2jCB4KvR5vjf58iL0kuCCYFGebS2EoiFFUzCMm0doRXBD8oo1-DFaYUxFXjPKnqJnIdzhZPAan6CTmgiS2ArFi8mqaJyFIfu8s9pvTBiz9zr-0Npmt1OEaO519vtXfj4a69op7jxEna-djWCssZvsRk_e2ZCB7bLbREfTpbCHvyaleN372R-ytfNR_3yOnvQwBP3i8D1FXy8-fFlf5defLj-uz69zxesy5kx0TABuhcK9Zj3lLVccKp7WFpR2HANwQnGnWtH1ZaPT4pS1VFMQrNRElafo3T53O7Wj7pS20cMgt96M4HfSgZF_E2u-yY27l6wUhKbxt4dx775POkQ5mqD0MIDVbgpSVKyqCMf_FUlVN3VVz4nFXlTehZCeZbkLwXKuU851yobIRs51poHXxxss-qG_xN8cOAQFQ-_BKhMWjVFeEs6OLjjHP9DlGNlPw5B6iUfn_VNM_NWe34Xo_CLQsmK8JuUfRHHNTQ</recordid><startdate>19940426</startdate><enddate>19940426</enddate><creator>WILSON, F. A. W</creator><creator>SCALADHE, S. P. O</creator><creator>GOLDMAN-RAKIC, P. S</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940426</creationdate><title>Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex</title><author>WILSON, F. A. W ; SCALADHE, S. P. O ; GOLDMAN-RAKIC, P. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-47d47a0b7c0fe4f25b5c5a65073722d50aa5120dcb7df39e09124b2e2a743e1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - physiology</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Histograms</topic><topic>Interneurons</topic><topic>Interneurons - physiology</topic><topic>Macaca mulatta</topic><topic>Memory - physiology</topic><topic>Mental stimulation</topic><topic>Neurobiology</topic><topic>Neurons</topic><topic>Neuroscience</topic><topic>Prefrontal cortex</topic><topic>Pyramidal cells</topic><topic>Reed Sternberg cells</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Pathways - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WILSON, F. A. W</creatorcontrib><creatorcontrib>SCALADHE, S. P. O</creatorcontrib><creatorcontrib>GOLDMAN-RAKIC, P. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WILSON, F. A. W</au><au>SCALADHE, S. P. O</au><au>GOLDMAN-RAKIC, P. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1994-04-26</date><risdate>1994</risdate><volume>91</volume><issue>9</issue><spage>4009</spage><epage>4013</epage><pages>4009-4013</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The responses of putative γ-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that γ-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with γ-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of γ-aminobutyratergic mechanisms in cognition.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8171027</pmid><doi>10.1073/pnas.91.9.4009</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1994-04, Vol.91 (9), p.4009-4013 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16898682 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Action Potentials Animals Biological and medical sciences Cerebral Cortex - physiology Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - physiology Histograms Interneurons Interneurons - physiology Macaca mulatta Memory - physiology Mental stimulation Neurobiology Neurons Neuroscience Prefrontal cortex Pyramidal cells Reed Sternberg cells Vertebrates: nervous system and sense organs Visual Pathways - physiology |
| title | Functional Synergism Between Putative γ-Aminobutyrate-Containing Neurons and Pyramidal Neurons in Prefrontal Cortex |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T03%3A08%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Functional%20Synergism%20Between%20Putative%20%CE%B3-Aminobutyrate-Containing%20Neurons%20and%20Pyramidal%20Neurons%20in%20Prefrontal%20Cortex&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=WILSON,%20F.%20A.%20W&rft.date=1994-04-26&rft.volume=91&rft.issue=9&rft.spage=4009&rft.epage=4013&rft.pages=4009-4013&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.91.9.4009&rft_dat=%3Cjstor_proqu%3E2364581%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16898682&rft_id=info:pmid/8171027&rft_jstor_id=2364581&rfr_iscdi=true |