Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia
To determine whether abnormal macular thickness in myopic anisometropic amblyopia differed after amblyopia treatment. Furthermore, to investigate whether effect of treatment on macular thickness was associated with subject age or improvement in stereoacuity. Seventeen children (mean age: 9.0 [±3.0]...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2015-04, Vol.56 (4), p.2677-2683 |
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| creator | Pang, Yi Frantz, Kelly A Block, Sandra Goodfellow, Geoffrey W Allison, Christine |
| description | To determine whether abnormal macular thickness in myopic anisometropic amblyopia differed after amblyopia treatment. Furthermore, to investigate whether effect of treatment on macular thickness was associated with subject age or improvement in stereoacuity.
Seventeen children (mean age: 9.0 [±3.0] years, ranging from 5.7-13.9 years) with myopic anisometropic amblyopia (visual acuity [VA] in amblyopic eyes: 20/80-20/400) were recruited and treated with 16-week refractive correction, followed by an additional 16-week refractive correction and patching. Macular thickness, best-corrected VA, and stereoacuity were measured both before and after amblyopia treatment. Factorial repeated-measures analysis of variance was performed to determine whether macular thickness in amblyopic eyes changed after amblyopia treatment.
Mean baseline VA in the amblyopic eye was 1.0 ± 0.3 logMAR and improved to 0.7 ± 0.3 after amblyopia treatment (P < 0.0001). The interaction between eye and amblyopia treatment was statistically significant for average foveal thickness (P = 0.040). There was no treatment effect on fellow eyes (P = 0.245); however, the average foveal thickness in the amblyopic eye was significantly reduced after amblyopia treatment (P = 0.049). No statistically significant interactions were found for the other macular thickness parameters (P > 0.05).
Abnormal central macula associated with myopic anisometropic amblyopia tended to be thinner following amblyopia treatment with no significant changes in peripheral macular thickness. |
| doi_str_mv | 10.1167/iovs.14-15532 |
| format | Article |
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Seventeen children (mean age: 9.0 [±3.0] years, ranging from 5.7-13.9 years) with myopic anisometropic amblyopia (visual acuity [VA] in amblyopic eyes: 20/80-20/400) were recruited and treated with 16-week refractive correction, followed by an additional 16-week refractive correction and patching. Macular thickness, best-corrected VA, and stereoacuity were measured both before and after amblyopia treatment. Factorial repeated-measures analysis of variance was performed to determine whether macular thickness in amblyopic eyes changed after amblyopia treatment.
Mean baseline VA in the amblyopic eye was 1.0 ± 0.3 logMAR and improved to 0.7 ± 0.3 after amblyopia treatment (P < 0.0001). The interaction between eye and amblyopia treatment was statistically significant for average foveal thickness (P = 0.040). There was no treatment effect on fellow eyes (P = 0.245); however, the average foveal thickness in the amblyopic eye was significantly reduced after amblyopia treatment (P = 0.049). No statistically significant interactions were found for the other macular thickness parameters (P > 0.05).
Abnormal central macula associated with myopic anisometropic amblyopia tended to be thinner following amblyopia treatment with no significant changes in peripheral macular thickness.</description><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.14-15532</identifier><identifier>PMID: 25788654</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Amblyopia - complications ; Amblyopia - pathology ; Amblyopia - therapy ; Anisometropia - complications ; Anisometropia - pathology ; Anisometropia - therapy ; Child ; Child, Preschool ; Eyeglasses ; Female ; Follow-Up Studies ; Humans ; Macula Lutea - pathology ; Male ; Myopia - complications ; Myopia - pathology ; Myopia - therapy ; Retinal Ganglion Cells - pathology ; Sensory Deprivation ; Tomography, Optical Coherence ; Treatment Outcome ; Visual Acuity</subject><ispartof>Investigative ophthalmology & visual science, 2015-04, Vol.56 (4), p.2677-2683</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-a0dd1d6d7a9360690477bbbc402eba215e6878a63103ab73128741ca6f319c9e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25788654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Yi</creatorcontrib><creatorcontrib>Frantz, Kelly A</creatorcontrib><creatorcontrib>Block, Sandra</creatorcontrib><creatorcontrib>Goodfellow, Geoffrey W</creatorcontrib><creatorcontrib>Allison, Christine</creatorcontrib><title>Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To determine whether abnormal macular thickness in myopic anisometropic amblyopia differed after amblyopia treatment. Furthermore, to investigate whether effect of treatment on macular thickness was associated with subject age or improvement in stereoacuity.
Seventeen children (mean age: 9.0 [±3.0] years, ranging from 5.7-13.9 years) with myopic anisometropic amblyopia (visual acuity [VA] in amblyopic eyes: 20/80-20/400) were recruited and treated with 16-week refractive correction, followed by an additional 16-week refractive correction and patching. Macular thickness, best-corrected VA, and stereoacuity were measured both before and after amblyopia treatment. Factorial repeated-measures analysis of variance was performed to determine whether macular thickness in amblyopic eyes changed after amblyopia treatment.
Mean baseline VA in the amblyopic eye was 1.0 ± 0.3 logMAR and improved to 0.7 ± 0.3 after amblyopia treatment (P < 0.0001). The interaction between eye and amblyopia treatment was statistically significant for average foveal thickness (P = 0.040). There was no treatment effect on fellow eyes (P = 0.245); however, the average foveal thickness in the amblyopic eye was significantly reduced after amblyopia treatment (P = 0.049). No statistically significant interactions were found for the other macular thickness parameters (P > 0.05).
Abnormal central macula associated with myopic anisometropic amblyopia tended to be thinner following amblyopia treatment with no significant changes in peripheral macular thickness.</description><subject>Adolescent</subject><subject>Amblyopia - complications</subject><subject>Amblyopia - pathology</subject><subject>Amblyopia - therapy</subject><subject>Anisometropia - complications</subject><subject>Anisometropia - pathology</subject><subject>Anisometropia - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Eyeglasses</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Macula Lutea - pathology</subject><subject>Male</subject><subject>Myopia - complications</subject><subject>Myopia - pathology</subject><subject>Myopia - therapy</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Sensory Deprivation</subject><subject>Tomography, Optical Coherence</subject><subject>Treatment Outcome</subject><subject>Visual Acuity</subject><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1PwzAQhi0EoqUwsiKPLCk-27GTsarKh1TEUsSG5TiOakjiYidI_fektEVMd_fquXd4ELoGMgUQ8s757zgFnkCaMnqCxsOkSSozdvpvH6GLGD8IoQCUnKMRHcJMpHyM3hdVZU2HfYVnTVFv_cZpvApWd41th7jFz9r0tQ54tXbms7UxYtfixdZG_Oa6NX7evRg8a130je3C_jpWXaKzStfRXh3mBL3eL1bzx2T58vA0ny0TwxjtEk3KEkpRSp0zQUROuJRFURhOqC00hdSKTGZaMCBMF5IBzSQHo0XFIDe5ZRN0u-_dBP_V29ipxkVj61q31vdRgcjyjHNCyIAme9QEH2OwldoE1-iwVUDUTqnaKVXA1a_Sgb85VPdFY8s_-uiQ_QDsQXJB</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Pang, Yi</creator><creator>Frantz, Kelly A</creator><creator>Block, Sandra</creator><creator>Goodfellow, Geoffrey W</creator><creator>Allison, Christine</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia</title><author>Pang, Yi ; Frantz, Kelly A ; Block, Sandra ; Goodfellow, Geoffrey W ; Allison, Christine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-a0dd1d6d7a9360690477bbbc402eba215e6878a63103ab73128741ca6f319c9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Amblyopia - complications</topic><topic>Amblyopia - pathology</topic><topic>Amblyopia - therapy</topic><topic>Anisometropia - complications</topic><topic>Anisometropia - pathology</topic><topic>Anisometropia - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Eyeglasses</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Macula Lutea - pathology</topic><topic>Male</topic><topic>Myopia - complications</topic><topic>Myopia - pathology</topic><topic>Myopia - therapy</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Sensory Deprivation</topic><topic>Tomography, Optical Coherence</topic><topic>Treatment Outcome</topic><topic>Visual Acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Yi</creatorcontrib><creatorcontrib>Frantz, Kelly A</creatorcontrib><creatorcontrib>Block, Sandra</creatorcontrib><creatorcontrib>Goodfellow, Geoffrey W</creatorcontrib><creatorcontrib>Allison, Christine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Yi</au><au>Frantz, Kelly A</au><au>Block, Sandra</au><au>Goodfellow, Geoffrey W</au><au>Allison, Christine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>56</volume><issue>4</issue><spage>2677</spage><epage>2683</epage><pages>2677-2683</pages><issn>1552-5783</issn><eissn>1552-5783</eissn><abstract>To determine whether abnormal macular thickness in myopic anisometropic amblyopia differed after amblyopia treatment. Furthermore, to investigate whether effect of treatment on macular thickness was associated with subject age or improvement in stereoacuity.
Seventeen children (mean age: 9.0 [±3.0] years, ranging from 5.7-13.9 years) with myopic anisometropic amblyopia (visual acuity [VA] in amblyopic eyes: 20/80-20/400) were recruited and treated with 16-week refractive correction, followed by an additional 16-week refractive correction and patching. Macular thickness, best-corrected VA, and stereoacuity were measured both before and after amblyopia treatment. Factorial repeated-measures analysis of variance was performed to determine whether macular thickness in amblyopic eyes changed after amblyopia treatment.
Mean baseline VA in the amblyopic eye was 1.0 ± 0.3 logMAR and improved to 0.7 ± 0.3 after amblyopia treatment (P < 0.0001). The interaction between eye and amblyopia treatment was statistically significant for average foveal thickness (P = 0.040). There was no treatment effect on fellow eyes (P = 0.245); however, the average foveal thickness in the amblyopic eye was significantly reduced after amblyopia treatment (P = 0.049). No statistically significant interactions were found for the other macular thickness parameters (P > 0.05).
Abnormal central macula associated with myopic anisometropic amblyopia tended to be thinner following amblyopia treatment with no significant changes in peripheral macular thickness.</abstract><cop>United States</cop><pmid>25788654</pmid><doi>10.1167/iovs.14-15532</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adolescent Amblyopia - complications Amblyopia - pathology Amblyopia - therapy Anisometropia - complications Anisometropia - pathology Anisometropia - therapy Child Child, Preschool Eyeglasses Female Follow-Up Studies Humans Macula Lutea - pathology Male Myopia - complications Myopia - pathology Myopia - therapy Retinal Ganglion Cells - pathology Sensory Deprivation Tomography, Optical Coherence Treatment Outcome Visual Acuity |
| title | Effect of Amblyopia Treatment on Macular Thickness in Eyes With Myopic Anisometropic Amblyopia |
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