Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis

Tetrandrine (TTD) is a calcium channel blocker with documented antifibrotic actions. In this study, for the first time, we identified that TTD can directly prevent in vitro human cardiac myofibroblast activation and limit in vivo myocardial fibrosis. In vitro, cardiac myofibroblasts from human atria...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2015-06, Vol.308 (12), p.H1564-H1574
Hauptverfasser:	Teng, Guoqi, Svystonyuk, Daniyil, Mewhort, Holly E M, Turnbull, Jeannine D, Belke, Darrell D, Duff, Henry J, Fedak, Paul W M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Actins - metabolism Animals Atrial Appendage - drug effects Atrial Appendage - metabolism Atrial Appendage - pathology Benzylisoquinolines - pharmacology Beta blockers Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Chelating Agents - pharmacology Cardiomyopathies - metabolism Cardiomyopathies - pathology Cardiomyopathies - physiopathology Cardiomyopathies - prevention & control Cardiovascular disease Cells, Cultured Collagen Collagen - genetics Collagen - metabolism Dose-Response Relationship, Drug Fibrosis Flow cytometry Gels Humans Hypertension - drug therapy Hypertension - metabolism Hypertension - pathology Hypertension - physiopathology Male Myofibroblasts - drug effects Myofibroblasts - metabolism Myofibroblasts - pathology Protein synthesis Rats, Inbred Dahl Ribonucleic acid RNA Time Factors Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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