Axon guidance proteins in neurological disorders
Summary Many neurological disorders are characterised by structural changes in neuronal connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire axon bundles. The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studi...
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Veröffentlicht in: | Lancet neurology 2015-05, Vol.14 (5), p.532-546 |
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description | Summary Many neurological disorders are characterised by structural changes in neuronal connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire axon bundles. The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studies suggest a role for axon guidance proteins. Axon guidance proteins guide growing axons during development and control structural plasticity of synaptic connections in adults. Changes in expression or function of these proteins might induce pathological changes in neural circuits that predispose to, or cause, neurological diseases. For some neurological disorders, such as midline crossing disorders, investigators have identified causative mutations in genes for axon guidance. However, for most other disorders, evidence is correlative and further studies are needed to confirm the pathological role of defects in proteins for axon guidance. Importantly, further insight into how dysregulation of axon guidance proteins causes disease will help the development of therapeutic strategies for neurological disorders. |
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The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studies suggest a role for axon guidance proteins. Axon guidance proteins guide growing axons during development and control structural plasticity of synaptic connections in adults. Changes in expression or function of these proteins might induce pathological changes in neural circuits that predispose to, or cause, neurological diseases. For some neurological disorders, such as midline crossing disorders, investigators have identified causative mutations in genes for axon guidance. However, for most other disorders, evidence is correlative and further studies are needed to confirm the pathological role of defects in proteins for axon guidance. Importantly, further insight into how dysregulation of axon guidance proteins causes disease will help the development of therapeutic strategies for neurological disorders.</description><identifier>ISSN: 1474-4422</identifier><identifier>EISSN: 1474-4465</identifier><identifier>DOI: 10.1016/S1474-4422(14)70257-1</identifier><identifier>PMID: 25769423</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alzheimer's disease ; Animals ; Axons - metabolism ; Axons - pathology ; Ephrins - metabolism ; Humans ; Mutation ; Nerve Growth Factor - metabolism ; Nerve Net - metabolism ; Nerve Net - pathology ; Nerve Tissue Proteins - metabolism ; Nervous System Diseases - metabolism ; Nervous System Diseases - pathology ; Neurological disorders ; Neurology ; Parkinson's disease ; Rodents ; Semaphorins - metabolism ; Studies</subject><ispartof>Lancet neurology, 2015-05, Vol.14 (5), p.532-546</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-544bdf63de38d19407250ed1ca43ef99cb182f35170c244070e919e0b340af3d3</citedby><cites>FETCH-LOGICAL-c500t-544bdf63de38d19407250ed1ca43ef99cb182f35170c244070e919e0b340af3d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1673859749?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000,64390,64392,64394,72474</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25769423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Battum, Eljo Y, MSc</creatorcontrib><creatorcontrib>Brignani, Sara, MSc</creatorcontrib><creatorcontrib>Pasterkamp, R Jeroen, Dr</creatorcontrib><title>Axon guidance proteins in neurological disorders</title><title>Lancet neurology</title><addtitle>Lancet Neurol</addtitle><description>Summary Many neurological disorders are characterised by structural changes in neuronal connections, ranging from presymptomatic synaptic changes to the loss or rewiring of entire axon bundles. The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studies suggest a role for axon guidance proteins. Axon guidance proteins guide growing axons during development and control structural plasticity of synaptic connections in adults. Changes in expression or function of these proteins might induce pathological changes in neural circuits that predispose to, or cause, neurological diseases. For some neurological disorders, such as midline crossing disorders, investigators have identified causative mutations in genes for axon guidance. However, for most other disorders, evidence is correlative and further studies are needed to confirm the pathological role of defects in proteins for axon guidance. Importantly, further insight into how dysregulation of axon guidance proteins causes disease will help the development of therapeutic strategies for neurological disorders.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Axons - metabolism</subject><subject>Axons - pathology</subject><subject>Ephrins - metabolism</subject><subject>Humans</subject><subject>Mutation</subject><subject>Nerve Growth Factor - metabolism</subject><subject>Nerve Net - metabolism</subject><subject>Nerve Net - pathology</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nervous System Diseases - metabolism</subject><subject>Nervous System Diseases - pathology</subject><subject>Neurological disorders</subject><subject>Neurology</subject><subject>Parkinson's disease</subject><subject>Rodents</subject><subject>Semaphorins - metabolism</subject><subject>Studies</subject><issn>1474-4422</issn><issn>1474-4465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkE1LAzEQhoMo1q-foCx4qYfVTJL9yEUpxS8oeFDPYZvMSnS70aQr9t-bbatCL54mJM-8M3kIOQZ6DhTyi0cQhUiFYGwI4qygLCtS2CJ76-s82_49MzYg-yG8UspAlLBLBhHOpWB8j9DRl2uTl86aqtWYvHs3R9uGxLZJi513jXuxumoSY4PzBn04JDt11QQ8WtcD8nxz_TS-SycPt_fj0STVGaXzNBNiauqcG-SlASlowTKKBnQlONZS6imUrOYZFFQzEZ8pSpBIp1zQquaGH5DhKjeu9NFhmKuZDRqbpmrRdUFBXsqcCShkRE830FfX-TZuF6mCl5ksRE9lK0p7F4LHWr17O6v8QgFVvVK1VKp6XwqEWipVEPtO1unddIbmt-vHYQSuVgBGHZ8WvQraYrRprEc9V8bZf0dcbiToxra99zdcYPj7jQpM0VVInxFrnwD8G-1RmEI</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Van Battum, Eljo Y, MSc</creator><creator>Brignani, Sara, MSc</creator><creator>Pasterkamp, R Jeroen, Dr</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C2</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Axon guidance proteins in neurological disorders</title><author>Van Battum, Eljo Y, MSc ; 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The molecular mechanisms that underlie this perturbed connectivity are poorly understood, but recent studies suggest a role for axon guidance proteins. Axon guidance proteins guide growing axons during development and control structural plasticity of synaptic connections in adults. Changes in expression or function of these proteins might induce pathological changes in neural circuits that predispose to, or cause, neurological diseases. For some neurological disorders, such as midline crossing disorders, investigators have identified causative mutations in genes for axon guidance. However, for most other disorders, evidence is correlative and further studies are needed to confirm the pathological role of defects in proteins for axon guidance. Importantly, further insight into how dysregulation of axon guidance proteins causes disease will help the development of therapeutic strategies for neurological disorders.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25769423</pmid><doi>10.1016/S1474-4422(14)70257-1</doi><tpages>15</tpages></addata></record> |
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subjects | Alzheimer's disease Animals Axons - metabolism Axons - pathology Ephrins - metabolism Humans Mutation Nerve Growth Factor - metabolism Nerve Net - metabolism Nerve Net - pathology Nerve Tissue Proteins - metabolism Nervous System Diseases - metabolism Nervous System Diseases - pathology Neurological disorders Neurology Parkinson's disease Rodents Semaphorins - metabolism Studies |
title | Axon guidance proteins in neurological disorders |
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