Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AML. Avocatin B reduced human primary AML cell viabi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-06, Vol.75 (12), p.2478-2488
Hauptverfasser:	Lee, Eric A, Angka, Leonard, Rota, Sarah-Grace, Hanlon, Thomas, Mitchell, Andrew, Hurren, Rose, Wang, Xiao Ming, Gronda, Marcela, Boyaci, Ezel, Bojko, Barbara, Minden, Mark, Sriskanthadevan, Shrivani, Datti, Alessandro, Wrana, Jeffery L, Edginton, Andrea, Pawliszyn, Janusz, Joseph, Jamie W, Quadrilatero, Joe, Schimmer, Aaron D, Spagnuolo, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Cell Death - drug effects Chromatography, Liquid - methods Fruit - chemistry High-Throughput Screening Assays - methods Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mass Spectrometry - methods Mice Mitochondria - drug effects Mitochondria - metabolism Oxidation-Reduction Persea - chemistry Plant Extracts - pharmacology Plant Oils - pharmacology Reactive Oxygen Species - metabolism Xenograft Model Antitumor Assays
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