Relationship between hepcidin and GDF15 in anemic patients with type 2 diabetes without overt renal impairment

Highlights • The serum level of GDF15 is highly expressed in patients with T2DM as an inflammatory cytokine. • Hepcidin is important protein to induce anemia of chronic disease. • The serum level of hepcidin is more increased and associated with risk factor for anemia in anemic patients with T2DM. •...

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Veröffentlicht in:	Diabetes research and clinical practice 2015-07, Vol.109 (1), p.64-70
Hauptverfasser:	Hong, Jun Hwa, Choi, Yeon-Kyung, Min, Byong-Keol, Park, Kang Seo, Seong, Kayeon, Lee, In Kyu, Kim, Jung Guk
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anemia Anemia - blood Anemia - etiology Chronic Disease Comorbidity Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Endocrinology & Metabolism Female Ferritins - blood GDF15 Growth Differentiation Factor 15 - blood Hepcidin Hepcidins - blood Humans Inflammation - blood Inflammation - complications Interleukin-6 - blood Male Middle Aged Renal Insufficiency - blood Renal Insufficiency - complications Type 2 diabetes
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Zusammenfassung:	Highlights • The serum level of GDF15 is highly expressed in patients with T2DM as an inflammatory cytokine. • Hepcidin is important protein to induce anemia of chronic disease. • The serum level of hepcidin is more increased and associated with risk factor for anemia in anemic patients with T2DM. • Hepcidin showed positive correlation to GDF15.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2015.05.001