Cockayne's syndrome fibroblasts characterized by hypersensitivity to deoxyguanosine and abnormal DNA precursor pool metabolism in response to deoxyguanosine or ultraviolet light

New cellular traits of Cockayne's syndrome (CS) associated with DNA precursor metabolism have been identified, namely, hypersensitivity to the toxicity of low concentrations of deoxyguanosine (dG) and abnormal changes in deoxyribonucleotide (dNTP) pools in response to dG or UV. dG treatment res...

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Veröffentlicht in:	Somatic cell and molecular genetics 1992-09, Vol.18 (5), p.387-401
Hauptverfasser:	SQUIRES, S, OATES, D. J, BOUFFLER, S. D, JOHNSON, R. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Division - drug effects Cell Survival - radiation effects Cells, Cultured Cockayne Syndrome - genetics Cockayne Syndrome - metabolism Complex syndromes Deoxyguanosine - toxicity Deoxyribonucleotides - metabolism DNA Fingerprinting DNA Repair Growth Inhibitors Humans Medical genetics Medical sciences Ultraviolet Rays
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