Ligand-binding properties of an unusual nicotinic acetylcholine receptor subtype on isolated outer hair cells from guinea pig cochlea

Acetylcholine receptors on isolated guinea pig cochlear outer hair cells (OHC) were characterized by radioligand binding. Equilibrium binding of [ I25]α-bungarotoxin revealed a K D of 62 ± 2 nM, B max = 7.2 ± 1.8 × 10 7 binding sites/OHC, and a slowly reversible dissociation rate constant, k −1 = 2....

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Veröffentlicht in:	Neuroscience letters 1995-07, Vol.195 (1), p.64-68
Hauptverfasser:	Lawoko, G., Järlebark, L., Heilbronn, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptor Animals Atropine - pharmacology Auditory system Binding, Competitive - drug effects Biological and medical sciences Bungarotoxins - metabolism Cochlea - cytology Cochlea - metabolism Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Efferent synapse Female Fundamental and applied biological sciences. Psychology Guinea Pigs Hair Cells, Auditory, Outer - metabolism In Vitro Techniques Ligands Male Muscarinic Antagonists - pharmacology Muscarinic ligands Nicotine - metabolism Nicotinic ligands Outer hair cell Parasympatholytics - pharmacology Piperidines - pharmacology Quinuclidinyl Benzilate - metabolism Radioligand Assay Radioligand binding Receptors, Nicotinic - metabolism Strychnine Strychnine - metabolism Vertebrates: nervous system and sense organs
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