Effects of allopurinol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurochemical changes in the striatum and in the brainstem of the rat

Levels of uric acid, xanthine, hypoxanthine, ascorbic acid (AA), dehydroascorbic acid (DHAA), glutathione (GSH), noradrenaline (NA), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ion (MP...

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Veröffentlicht in:	Neuroscience letters 1995-01, Vol.183 (3), p.155-159
Hauptverfasser:	Miele, M., Esposito, G., Migheli, R., Sircana, S., Zangani, D., Fresu, G.L., Desole, M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - antagonists & inhibitors 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - metabolism 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology 1-Methyl-4-phenylpyridinium - metabolism 1-Methyl-4-phenylpyridinium ion Allopurinol - pharmacology Animals Ascorbic Acid - metabolism Brain Stem - drug effects Brain Stem - metabolism Brainstem Dopamine - metabolism Dopamine - physiology Glutathione - metabolism Hypoxanthine Hypoxanthines - metabolism Male Neostriatum - drug effects Neostriatum - metabolism Norepinephrine - physiology Oxidative stress Rat Rats Rats, Wistar Striatum Uric acid Uric Acid - metabolism Xanthine oxidase Xanthines - metabolism
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