Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond
Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or aborti...
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Veröffentlicht in: | Contraception (Stoneham) 2015-07, Vol.92 (1), p.17-25 |
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description | Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p < .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods. |
doi_str_mv | 10.1016/j.contraception.2015.03.012 |
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Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p < .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2015.03.012</identifier><identifier>PMID: 25818594</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abortion, Induced - statistics & numerical data ; Adolescent ; Adult ; Aftercare ; Contraception - methods ; Contraception - statistics & numerical data ; Contraceptive Agents, Female - administration & dosage ; Copper multiload Cu375 intrauterine device ; Female ; Humans ; Incidence ; Intrauterine Devices, Medicated - statistics & numerical data ; Levonorgestrel - administration & dosage ; Levonorgestrel intrauterine system ; Levonorgestrel-releasing subdermal implant ; Long-acting reversible contraception (LARC) ; New Zealand ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Unintended pregnancy ; Young Adult</subject><ispartof>Contraception (Stoneham), 2015-07, Vol.92 (1), p.17-25</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</citedby><cites>FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010782415001304$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rose, Sally B</creatorcontrib><creatorcontrib>Garrett, Susan M</creatorcontrib><creatorcontrib>Stanley, James</creatorcontrib><title>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p < .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</description><subject>Abortion, Induced - statistics & numerical data</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aftercare</subject><subject>Contraception - methods</subject><subject>Contraception - statistics & numerical data</subject><subject>Contraceptive Agents, Female - administration & dosage</subject><subject>Copper multiload Cu375 intrauterine device</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intrauterine Devices, Medicated - statistics & numerical data</subject><subject>Levonorgestrel - administration & dosage</subject><subject>Levonorgestrel intrauterine system</subject><subject>Levonorgestrel-releasing subdermal implant</subject><subject>Long-acting reversible contraception (LARC)</subject><subject>New Zealand</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><subject>Unintended pregnancy</subject><subject>Young Adult</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1TAQtBCofS39BWSJC5cErx0njpCQUFVKpUocWs5WYm-oH0kcbKfSu_HpOHotEpw4eW3PzGpnlpC3wEpgUL_fl8bPKXQGl-T8XHIGsmSiZMBfkB2opi2YBPWS7BgDVjSKV6fkLMY9Y6xpZXNCTrlUoGRb7civm2lC67qEdPExdb0Pmyh1s0v5dSv9QEd89LMP3zGmgCN10zJ2c4o0oF0NRpoeMDOMszgb3Ai9C-kh0m629Fky3xLl9IBdOH70ePCzfU1eDd0Y8eLpPCffPl_dX34pbr9e31x-ui2MZCoVQ28lAghlqx45QJ6wb4QdqtYiN6K2gxoAbMMl9lJwVFKyVjU1UzWooa7EOXl31F2C_7nmQfTkosExD4J-jRpq1QrgvGoz9MMRaoKPMeCgl-CmLhw0ML1FoPf6rwj0FoFmQucIMvvNU6O1z9b-4T57ngFXRwDmcR8dBh2N24yzLqBJ2nr3n40-_qNjxhyb6cYfeMC492uYs6MadOSa6bttG7ZlAJkrwSrxG4RLtt0</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Rose, Sally B</creator><creator>Garrett, Susan M</creator><creator>Stanley, James</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</title><author>Rose, Sally B ; Garrett, Susan M ; Stanley, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abortion, Induced - statistics & numerical data</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aftercare</topic><topic>Contraception - methods</topic><topic>Contraception - statistics & numerical data</topic><topic>Contraceptive Agents, Female - administration & dosage</topic><topic>Copper multiload Cu375 intrauterine device</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intrauterine Devices, Medicated - statistics & numerical data</topic><topic>Levonorgestrel - administration & dosage</topic><topic>Levonorgestrel intrauterine system</topic><topic>Levonorgestrel-releasing subdermal implant</topic><topic>Long-acting reversible contraception (LARC)</topic><topic>New Zealand</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><topic>Unintended pregnancy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rose, Sally B</creatorcontrib><creatorcontrib>Garrett, Susan M</creatorcontrib><creatorcontrib>Stanley, James</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rose, Sally B</au><au>Garrett, Susan M</au><au>Stanley, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>92</volume><issue>1</issue><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><abstract>Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p < .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25818594</pmid><doi>10.1016/j.contraception.2015.03.012</doi><tpages>9</tpages></addata></record> |
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subjects | Abortion, Induced - statistics & numerical data Adolescent Adult Aftercare Contraception - methods Contraception - statistics & numerical data Contraceptive Agents, Female - administration & dosage Copper multiload Cu375 intrauterine device Female Humans Incidence Intrauterine Devices, Medicated - statistics & numerical data Levonorgestrel - administration & dosage Levonorgestrel intrauterine system Levonorgestrel-releasing subdermal implant Long-acting reversible contraception (LARC) New Zealand Obstetrics and Gynecology Pregnancy Pregnancy Rate Retrospective Studies Unintended pregnancy Young Adult |
title | Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond |
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