Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond

Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or aborti...

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Veröffentlicht in:Contraception (Stoneham) 2015-07, Vol.92 (1), p.17-25
Hauptverfasser: Rose, Sally B, Garrett, Susan M, Stanley, James
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creator Rose, Sally B
Garrett, Susan M
Stanley, James
description Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p < .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.
doi_str_mv 10.1016/j.contraception.2015.03.012
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Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p &lt; .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</description><identifier>ISSN: 0010-7824</identifier><identifier>EISSN: 1879-0518</identifier><identifier>DOI: 10.1016/j.contraception.2015.03.012</identifier><identifier>PMID: 25818594</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abortion, Induced - statistics &amp; numerical data ; Adolescent ; Adult ; Aftercare ; Contraception - methods ; Contraception - statistics &amp; numerical data ; Contraceptive Agents, Female - administration &amp; dosage ; Copper multiload Cu375 intrauterine device ; Female ; Humans ; Incidence ; Intrauterine Devices, Medicated - statistics &amp; numerical data ; Levonorgestrel - administration &amp; dosage ; Levonorgestrel intrauterine system ; Levonorgestrel-releasing subdermal implant ; Long-acting reversible contraception (LARC) ; New Zealand ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; Unintended pregnancy ; Young Adult</subject><ispartof>Contraception (Stoneham), 2015-07, Vol.92 (1), p.17-25</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</citedby><cites>FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0010782415001304$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818594$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rose, Sally B</creatorcontrib><creatorcontrib>Garrett, Susan M</creatorcontrib><creatorcontrib>Stanley, James</creatorcontrib><title>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</title><title>Contraception (Stoneham)</title><addtitle>Contraception</addtitle><description>Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p &lt; .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</description><subject>Abortion, Induced - statistics &amp; numerical data</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aftercare</subject><subject>Contraception - methods</subject><subject>Contraception - statistics &amp; numerical data</subject><subject>Contraceptive Agents, Female - administration &amp; dosage</subject><subject>Copper multiload Cu375 intrauterine device</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intrauterine Devices, Medicated - statistics &amp; numerical data</subject><subject>Levonorgestrel - administration &amp; dosage</subject><subject>Levonorgestrel intrauterine system</subject><subject>Levonorgestrel-releasing subdermal implant</subject><subject>Long-acting reversible contraception (LARC)</subject><subject>New Zealand</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><subject>Unintended pregnancy</subject><subject>Young Adult</subject><issn>0010-7824</issn><issn>1879-0518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1TAQtBCofS39BWSJC5cErx0njpCQUFVKpUocWs5WYm-oH0kcbKfSu_HpOHotEpw4eW3PzGpnlpC3wEpgUL_fl8bPKXQGl-T8XHIGsmSiZMBfkB2opi2YBPWS7BgDVjSKV6fkLMY9Y6xpZXNCTrlUoGRb7civm2lC67qEdPExdb0Pmyh1s0v5dSv9QEd89LMP3zGmgCN10zJ2c4o0oF0NRpoeMDOMszgb3Ai9C-kh0m629Fky3xLl9IBdOH70ePCzfU1eDd0Y8eLpPCffPl_dX34pbr9e31x-ui2MZCoVQ28lAghlqx45QJ6wb4QdqtYiN6K2gxoAbMMl9lJwVFKyVjU1UzWooa7EOXl31F2C_7nmQfTkosExD4J-jRpq1QrgvGoz9MMRaoKPMeCgl-CmLhw0ML1FoPf6rwj0FoFmQucIMvvNU6O1z9b-4T57ngFXRwDmcR8dBh2N24yzLqBJ2nr3n40-_qNjxhyb6cYfeMC492uYs6MadOSa6bttG7ZlAJkrwSrxG4RLtt0</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Rose, Sally B</creator><creator>Garrett, Susan M</creator><creator>Stanley, James</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</title><author>Rose, Sally B ; Garrett, Susan M ; Stanley, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-fbd5e1138d4be211051b73df49de2c36df8f11d725eb532e8550987608618f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abortion, Induced - statistics &amp; numerical data</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aftercare</topic><topic>Contraception - methods</topic><topic>Contraception - statistics &amp; numerical data</topic><topic>Contraceptive Agents, Female - administration &amp; dosage</topic><topic>Copper multiload Cu375 intrauterine device</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intrauterine Devices, Medicated - statistics &amp; numerical data</topic><topic>Levonorgestrel - administration &amp; dosage</topic><topic>Levonorgestrel intrauterine system</topic><topic>Levonorgestrel-releasing subdermal implant</topic><topic>Long-acting reversible contraception (LARC)</topic><topic>New Zealand</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><topic>Unintended pregnancy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rose, Sally B</creatorcontrib><creatorcontrib>Garrett, Susan M</creatorcontrib><creatorcontrib>Stanley, James</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contraception (Stoneham)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rose, Sally B</au><au>Garrett, Susan M</au><au>Stanley, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond</atitle><jtitle>Contraception (Stoneham)</jtitle><addtitle>Contraception</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>92</volume><issue>1</issue><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0010-7824</issn><eissn>1879-0518</eissn><abstract>Abstract Objectives The aims of this study were to compare immediate postabortion uptake of recently subsidized (no-cost) levonorgestrel-releasing implants with already available intrauterine and shorter-acting methods and to compare the incidence of subsequent pregnancies (ending in birth or abortion) within 2 years. Study design Retrospective chart review of 4698 women attending a New Zealand public hospital abortion clinic over 2 years (2010–2012) to describe postabortion contraceptive choice, with follow-up via clinic and national births records to assess subsequent pregnancies at 12, 24, 36, and 48 months. Results Twenty percent of the cohort (934/4698) received an implant, 26% an intrauterine method (927 copper intrauterine device, 301 levonorgestrel-releasing intrauterine system [LNG-IUS]), and 54% chose other shorter-acting methods (2536/4698). Method choice was significantly associated with age, ethnicity, and pregnancy history ( p &lt; .001). At 24 months, the unadjusted incidence of subsequent abortion for implant users was 3.8% (95% confidence interval [CI] = 2.5–5.0) and 11.6% (95% CI = 10.3–12.8) for those choosing other short-acting methods. By 48 months, 6.6% of implant users had a subsequent abortion (compared with 18.3% for short-acting methods). The incidence of continued pregnancy at 24 months was 6.3% (95% CI = 4.4–8.1) for implant users and 15.7% (95% CI = 14–17.2) for those choosing other short-acting methods. Adjusted hazard ratios (HRs) for subsequent abortion were lowest for women initiating an implant (HR = 0.26, 95% CI = 0.20–0.35) or LNG-IUS (HR = 0.26, 0.16–0.44, reference group: short-acting methods). Conclusions Immediate postabortion insertion of an implant significantly reduced rates of subsequent pregnancy for at least 2 years. Abortion service providers should ensure women have barrier-free access to all long-acting reversible contraceptions to delay or prevent pregnancy. Implications Initiation of an levonorgestrel implant immediately postabortion was associated with a 74% reduction in subsequent abortion over the next 4 years compared with use of short-acting methods. Implants were popular among adolescents—a group at high-risk of subsequent pregnancy, and who have not historically been considered appropriate candidates for intrauterine contraceptive methods.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25818594</pmid><doi>10.1016/j.contraception.2015.03.012</doi><tpages>9</tpages></addata></record>
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subjects Abortion, Induced - statistics & numerical data
Adolescent
Adult
Aftercare
Contraception - methods
Contraception - statistics & numerical data
Contraceptive Agents, Female - administration & dosage
Copper multiload Cu375 intrauterine device
Female
Humans
Incidence
Intrauterine Devices, Medicated - statistics & numerical data
Levonorgestrel - administration & dosage
Levonorgestrel intrauterine system
Levonorgestrel-releasing subdermal implant
Long-acting reversible contraception (LARC)
New Zealand
Obstetrics and Gynecology
Pregnancy
Pregnancy Rate
Retrospective Studies
Unintended pregnancy
Young Adult
title Immediate postabortion initiation of levonorgestrel implants reduces the incidence of births and abortions at 2 years and beyond
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