Effects of Cremophor EL on the absorption of orally administered saquinavir and fexofenadine in healthy subjects

Modulation of CYP3A and/or P-gp function by several excipients has been reported. However, relatively few studies have investigated their effects in humans. Therefore, the aim of this clinical study was to clarify the effects of Cremophor EL on the inhibition of CYP3A and P-gp in the human small int...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2015-06, Vol.30 (3), p.221-226
Hauptverfasser:	Tomaru, Atsuko, Takeda-Morishita, Mariko, Maeda, Kazuya, Banba, Hirokazu, Takayama, Kozo, Kumagai, Yuji, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption, Physiological Administration, Oral ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Cremophor EL Cross-Over Studies Cytochrome P-450 CYP3A - metabolism Excipients - chemistry Excipients - pharmacology Fexofenadine Glycerol - analogs & derivatives Glycerol - chemistry Glycerol - pharmacology Healthy Volunteers Humans Male Oral absorption P-gp Saquinavir Saquinavir - administration & dosage Saquinavir - blood Saquinavir - chemistry Substrate Specificity Terfenadine - administration & dosage Terfenadine - analogs & derivatives Terfenadine - blood Terfenadine - chemistry
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