Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy
Abstract Background The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC. Methods All consecutive patients with locally advanced gastroe...
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| Veröffentlicht in: | The American journal of surgery 2015-07, Vol.210 (1), p.15-23 |
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| creator | Luc, Guillaume, M.D Gersen-Cherdieu, Hélène, M.D Degrandi, Olivier, M.D Terrebonne, Eric, M.D Chiche, Laurence, M.D., Ph.D Collet, Denis, M.D., Ph.D |
| description | Abstract Background The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC. Methods All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated by perioperative chemotherapy (PCT) at our center were selected. Overall survival and disease-free survival were compared in patients who did not undergo planned POC (nondelivery of nPOC group) and patients who underwent POC (POC group). Results Among 385 patients who underwent esophagectomies or gastrectomies, PCT was performed in 110 patients. Of these, 74 (67%) patients underwent POC. Predictors of overall survival included postoperative morbidity, pT3-4 stage, R1 resection, and delivery of more than 1 cycle of POC. Factors predicting POC application included postoperative morbidity, esophagectomy, and body mass index. Conclusions Two cycles of POC were necessary to improve survival in patients with gastroesophageal adenocarcinoma. |
| doi_str_mv | 10.1016/j.amjsurg.2014.12.036 |
| format | Article |
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Methods All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated by perioperative chemotherapy (PCT) at our center were selected. Overall survival and disease-free survival were compared in patients who did not undergo planned POC (nondelivery of nPOC group) and patients who underwent POC (POC group). Results Among 385 patients who underwent esophagectomies or gastrectomies, PCT was performed in 110 patients. Of these, 74 (67%) patients underwent POC. Predictors of overall survival included postoperative morbidity, pT3-4 stage, R1 resection, and delivery of more than 1 cycle of POC. Factors predicting POC application included postoperative morbidity, esophagectomy, and body mass index. Conclusions Two cycles of POC were necessary to improve survival in patients with gastroesophageal adenocarcinoma.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2014.12.036</identifier><identifier>PMID: 25957032</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adenocarcinoma - drug therapy ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Anesthesiology ; Body mass index ; Cancer therapies ; Chemotherapy ; Chemotherapy, Adjuvant ; Confidence intervals ; Esophageal Neoplasms - drug therapy ; Esophageal Neoplasms - surgery ; Esophagectomy ; Esophagogastric Junction ; Female ; Gastroesophageal adenocarcinoma ; Humans ; Male ; Medical prognosis ; Middle Aged ; Morbidity ; Neoplasm Staging ; Perioperative chemotherapy ; Postoperative Care ; Postoperative chemotherapy ; Retrospective Studies ; Stomach ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - surgery ; Surgery ; Tomography ; Young Adult</subject><ispartof>The American journal of surgery, 2015-07, Vol.210 (1), p.15-23</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jul 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-a9c0755a11088638213eab03137569680a1dad05f9571759d11d7289a96de353</citedby><cites>FETCH-LOGICAL-c448t-a9c0755a11088638213eab03137569680a1dad05f9571759d11d7289a96de353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002961015001324$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25957032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luc, Guillaume, M.D</creatorcontrib><creatorcontrib>Gersen-Cherdieu, Hélène, M.D</creatorcontrib><creatorcontrib>Degrandi, Olivier, M.D</creatorcontrib><creatorcontrib>Terrebonne, Eric, M.D</creatorcontrib><creatorcontrib>Chiche, Laurence, M.D., Ph.D</creatorcontrib><creatorcontrib>Collet, Denis, M.D., Ph.D</creatorcontrib><title>Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC. Methods All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated by perioperative chemotherapy (PCT) at our center were selected. Overall survival and disease-free survival were compared in patients who did not undergo planned POC (nondelivery of nPOC group) and patients who underwent POC (POC group). Results Among 385 patients who underwent esophagectomies or gastrectomies, PCT was performed in 110 patients. Of these, 74 (67%) patients underwent POC. Predictors of overall survival included postoperative morbidity, pT3-4 stage, R1 resection, and delivery of more than 1 cycle of POC. Factors predicting POC application included postoperative morbidity, esophagectomy, and body mass index. Conclusions Two cycles of POC were necessary to improve survival in patients with gastroesophageal adenocarcinoma.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesiology</subject><subject>Body mass index</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Confidence intervals</subject><subject>Esophageal Neoplasms - drug therapy</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Esophagogastric Junction</subject><subject>Female</subject><subject>Gastroesophageal adenocarcinoma</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Neoplasm Staging</subject><subject>Perioperative chemotherapy</subject><subject>Postoperative Care</subject><subject>Postoperative chemotherapy</subject><subject>Retrospective Studies</subject><subject>Stomach</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgery</subject><subject>Tomography</subject><subject>Young Adult</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks-O1DAMxisEYoeFRwBV4sKlJU6aNr2A0Io_K63Egb1H2dQzk9I2JckM6pPwurjMANJKiFPk5PfZsT9n2XNgJTCoX_elGft4CLuSM6hK4CUT9YNsA6ppC1BKPMw2jDFetDWwi-xJjD2FAJV4nF1w2cqGCb7JflyPs7Ep99t89jH5GYNJ7oi53ePo057CecndlM90jVOK-XeX9vngrRmGJTfd0UwWu3xnYgoeo5_3ZodmoBecCArWTX40eQpoEnG_1FTE_aMSZSFutzzNHm3NEPHZ-bzMbj-8v736VNx8_nh99e6msFWlUmFayxopDQBTqhaKg0BzxwSIRtZtrZiBznRMbqlfaGTbAXQNV61p6w6FFJfZq1PaOfhvB4xJjy5aHAYzoT9EDbVqBQBnjNCX99DeH8JEn1spVcmWNxVR8kTZ4GMMuNVzcKMJiwamV-N0r8_G6dU4DVyTcaR7cc5-uBux-6P67RQBb08A0jSODoOOlgyh2buANunOu_-WeHMvgx3c5MjIr7hg_NuNjiTQX9btWZcHJO2N4JX4CUKTxE4</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Luc, Guillaume, M.D</creator><creator>Gersen-Cherdieu, Hélène, M.D</creator><creator>Degrandi, Olivier, M.D</creator><creator>Terrebonne, Eric, M.D</creator><creator>Chiche, Laurence, M.D., Ph.D</creator><creator>Collet, Denis, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150701</creationdate><title>Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy</title><author>Luc, Guillaume, M.D ; Gersen-Cherdieu, Hélène, M.D ; Degrandi, Olivier, M.D ; Terrebonne, Eric, M.D ; Chiche, Laurence, M.D., Ph.D ; Collet, Denis, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-a9c0755a11088638213eab03137569680a1dad05f9571759d11d7289a96de353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesiology</topic><topic>Body mass index</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Confidence intervals</topic><topic>Esophageal Neoplasms - drug therapy</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy</topic><topic>Esophagogastric Junction</topic><topic>Female</topic><topic>Gastroesophageal adenocarcinoma</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Neoplasm Staging</topic><topic>Perioperative chemotherapy</topic><topic>Postoperative Care</topic><topic>Postoperative chemotherapy</topic><topic>Retrospective Studies</topic><topic>Stomach</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgery</topic><topic>Tomography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luc, Guillaume, M.D</creatorcontrib><creatorcontrib>Gersen-Cherdieu, Hélène, M.D</creatorcontrib><creatorcontrib>Degrandi, Olivier, M.D</creatorcontrib><creatorcontrib>Terrebonne, Eric, M.D</creatorcontrib><creatorcontrib>Chiche, Laurence, M.D., Ph.D</creatorcontrib><creatorcontrib>Collet, Denis, M.D., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luc, Guillaume, M.D</au><au>Gersen-Cherdieu, Hélène, M.D</au><au>Degrandi, Olivier, M.D</au><au>Terrebonne, Eric, M.D</au><au>Chiche, Laurence, M.D., Ph.D</au><au>Collet, Denis, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>210</volume><issue>1</issue><spage>15</spage><epage>23</epage><pages>15-23</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background The aim of this study was to determine the clinical impact of postoperative chemotherapy (POC) in patients with locally advanced gastroesophageal adenocarcinoma and determine the predictors of delivery of planned POC. Methods All consecutive patients with locally advanced gastroesophageal adenocarcinoma treated by perioperative chemotherapy (PCT) at our center were selected. Overall survival and disease-free survival were compared in patients who did not undergo planned POC (nondelivery of nPOC group) and patients who underwent POC (POC group). Results Among 385 patients who underwent esophagectomies or gastrectomies, PCT was performed in 110 patients. Of these, 74 (67%) patients underwent POC. Predictors of overall survival included postoperative morbidity, pT3-4 stage, R1 resection, and delivery of more than 1 cycle of POC. Factors predicting POC application included postoperative morbidity, esophagectomy, and body mass index. Conclusions Two cycles of POC were necessary to improve survival in patients with gastroesophageal adenocarcinoma.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25957032</pmid><doi>10.1016/j.amjsurg.2014.12.036</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenocarcinoma - drug therapy Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Aged, 80 and over Anesthesiology Body mass index Cancer therapies Chemotherapy Chemotherapy, Adjuvant Confidence intervals Esophageal Neoplasms - drug therapy Esophageal Neoplasms - surgery Esophagectomy Esophagogastric Junction Female Gastroesophageal adenocarcinoma Humans Male Medical prognosis Middle Aged Morbidity Neoplasm Staging Perioperative chemotherapy Postoperative Care Postoperative chemotherapy Retrospective Studies Stomach Stomach Neoplasms - drug therapy Stomach Neoplasms - surgery Surgery Tomography Young Adult |
| title | Impact of postoperative chemotherapy in patients with locally advanced gastroesophageal adenocarcinoma treated with perioperative chemotherapy strategy |
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