Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II
Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein...
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| Veröffentlicht in: | Internal Medicine 2015, Vol.54(12), pp.1531-1536 |
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| creator | Akutsu, Noriyuki Adachi, Yasushi Isosaka, Mai Mita, Hiroaki Takagi, Hideyasu Sasaki, Shigeru Yamamoto, Hiroyuki Arimura, Yoshiaki Ishii, Yoshifumi Masumori, Naoya Endo, Takao Shinomura, Yasuhisa |
| description | Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma. |
| doi_str_mv | 10.2169/internalmedicine.54.4025 |
| format | Article |
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We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. 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Med.</addtitle><description>Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. In the current report, we describe this case of PIVKA-II-producing YST and review previous cases of PIVKA-II-producing tumors other than hepatoma.</description><subject>Aged</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Autopsy</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Endodermal Sinus Tumor - chemistry</subject><subject>Endodermal Sinus Tumor - diagnosis</subject><subject>extragonadal</subject><subject>Fatal Outcome</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Liver Neoplasms - chemistry</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Lung Neoplasms - chemistry</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Male</subject><subject>Mediastinal Neoplasms - chemistry</subject><subject>Mediastinal Neoplasms - diagnosis</subject><subject>mediastinum</subject><subject>PIVKA-II</subject><subject>Protein Precursors - analysis</subject><subject>Prothrombin - analysis</subject><subject>Vitamin K - analysis</subject><subject>yolk sac tumor</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1u2zAQhIkiQeO4fYWCx1zk8leijoaRpEZdJEDSAu2FoKhVSkeiHJI65O1Lw44PRS5LYvebWewghClZMFrWX51PELzpB2iddR4WUiwEYfIDmlEu6qJiXJ6hGampKlguF-gyxi0hXFU1-4guWEkqzoScoT8_soWJyWU3_Hvsn_GDsfhxGsaA78PYTtn-af9L4Dxe-9yAFjev-JdLZsit73jZRPAWcFYsfTJPo3cxFev1J3TemT7C5-M7Rz9vrh9X34rN3e16tdwUViqRCk5BcdExxWkpaSNpSWjbUVUJSZquJKoBLlXbmJqLqoLWWmLKlpcVz4fVtuVzdHXw3YXxZYKY9OCihb43HsYpalqqmlOS782oOqA2jDEG6PQuuMGEV02J3ier_09WS6H3yWbpl-OWqcnDk_AtygzcHYBtzCHACTAhOdvDu86U7etxxYm0f03Q4Pk_8diWCA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Akutsu, Noriyuki</creator><creator>Adachi, Yasushi</creator><creator>Isosaka, Mai</creator><creator>Mita, Hiroaki</creator><creator>Takagi, Hideyasu</creator><creator>Sasaki, Shigeru</creator><creator>Yamamoto, Hiroyuki</creator><creator>Arimura, Yoshiaki</creator><creator>Ishii, Yoshifumi</creator><creator>Masumori, Naoya</creator><creator>Endo, Takao</creator><creator>Shinomura, Yasuhisa</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II</title><author>Akutsu, Noriyuki ; Adachi, Yasushi ; Isosaka, Mai ; Mita, Hiroaki ; Takagi, Hideyasu ; Sasaki, Shigeru ; Yamamoto, Hiroyuki ; Arimura, Yoshiaki ; Ishii, Yoshifumi ; Masumori, Naoya ; Endo, Takao ; Shinomura, Yasuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-31e834f2831651b51601df187450bf608be358dba93477edcc0a6d36739189cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>alpha-Fetoproteins - analysis</topic><topic>Autopsy</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Endodermal Sinus Tumor - chemistry</topic><topic>Endodermal Sinus Tumor - diagnosis</topic><topic>extragonadal</topic><topic>Fatal Outcome</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Liver Neoplasms - chemistry</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Lung Neoplasms - chemistry</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Male</topic><topic>Mediastinal Neoplasms - chemistry</topic><topic>Mediastinal Neoplasms - diagnosis</topic><topic>mediastinum</topic><topic>PIVKA-II</topic><topic>Protein Precursors - analysis</topic><topic>Prothrombin - analysis</topic><topic>Vitamin K - analysis</topic><topic>yolk sac tumor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akutsu, Noriyuki</creatorcontrib><creatorcontrib>Adachi, Yasushi</creatorcontrib><creatorcontrib>Isosaka, Mai</creatorcontrib><creatorcontrib>Mita, Hiroaki</creatorcontrib><creatorcontrib>Takagi, Hideyasu</creatorcontrib><creatorcontrib>Sasaki, Shigeru</creatorcontrib><creatorcontrib>Yamamoto, Hiroyuki</creatorcontrib><creatorcontrib>Arimura, Yoshiaki</creatorcontrib><creatorcontrib>Ishii, Yoshifumi</creatorcontrib><creatorcontrib>Masumori, Naoya</creatorcontrib><creatorcontrib>Endo, Takao</creatorcontrib><creatorcontrib>Shinomura, Yasuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akutsu, Noriyuki</au><au>Adachi, Yasushi</au><au>Isosaka, Mai</au><au>Mita, Hiroaki</au><au>Takagi, Hideyasu</au><au>Sasaki, Shigeru</au><au>Yamamoto, Hiroyuki</au><au>Arimura, Yoshiaki</au><au>Ishii, Yoshifumi</au><au>Masumori, Naoya</au><au>Endo, Takao</au><au>Shinomura, Yasuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>12</issue><spage>1531</spage><epage>1536</epage><pages>1531-1536</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Extragonadal yolk sac tumors (YSTs) are rare. We herein report the case of a 66-year-old man with mediastinal, lung and liver tumors. The largest mass was located in the liver and contained a high concentration of protein induced by vitamin K absence or antagonist-II (PIVKA-II) and alpha-fetoprotein. Therefore, the lesion was difficult to distinguish from hepatocellular carcinoma. Finally, YST was diagnosed based on the results of a liver biopsy. Although chemotherapy was effective, the patient died of respiratory failure. The autopsy revealed primary mediastinal YST. 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| subjects | Aged alpha-Fetoproteins - analysis Autopsy Biomarkers - analysis Biomarkers, Tumor - analysis Carcinoma, Hepatocellular - diagnosis Diagnosis, Differential Endodermal Sinus Tumor - chemistry Endodermal Sinus Tumor - diagnosis extragonadal Fatal Outcome Humans Immunohistochemistry Liver Neoplasms - chemistry Liver Neoplasms - diagnosis Lung Neoplasms - chemistry Lung Neoplasms - diagnosis Male Mediastinal Neoplasms - chemistry Mediastinal Neoplasms - diagnosis mediastinum PIVKA-II Protein Precursors - analysis Prothrombin - analysis Vitamin K - analysis yolk sac tumor |
| title | Mediastinal Yolk Sac Tumor Producing Protein Induced by Vitamin K Absence or Antagonist-II |
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