Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

Abstract Background Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Methods Blood exosomes obtained at one time-point from patients with AD (n = 57) or frontotemporal dementi...

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Veröffentlicht in:	Alzheimer's & dementia 2015-06, Vol.11 (6), p.600-607.e1
Hauptverfasser:	Fiandaca, Massimo S, Kapogiannis, Dimitrios, Mapstone, Mark, Boxer, Adam, Eitan, Erez, Schwartz, Janice B, Abner, Erin L, Petersen, Ronald C, Federoff, Howard J, Miller, Bruce L, Goetzl, Edward J
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - classification Amyloid beta-Peptides - blood Aβ1–42 Biomarkers Biomarkers - blood Case-Control Studies Cross-Sectional Studies Discriminant Analysis Enzyme-Linked Immunosorbent Assay Exosomes - metabolism Female Frontotemporal Dementia - blood Frontotemporal Dementia - classification Humans Male Middle Aged Neural exosomes Neurology P-Tau Peptide Fragments - blood Phosphorylation Preclinical AD Prodromal Symptoms Retrospective Studies Severity of Illness Index tau Proteins - blood Time Factors
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