A Predictive Substrate Model for Rat Glutathione S-Transferase 4-4

Molecular modeling techniques have been used to derive a substrate model for class mu rat glutathione S-transferase 4-4 (GST 4-4). Information on regio- and stereoselective product formation of 20 substrates covering three chemically and structurally different classes was used to construct a substra...

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Veröffentlicht in:	Chemical research in toxicology 1995-07, Vol.8 (5), p.649-658
Hauptverfasser:	de Groot, Marcel J, Van der Aar, Ellen M, Nieuwenhuizen, Peter J, Van der Plas, R. Martijn, Kelder, Gabrieelle M. Donne, Commandeur, Jan N. M, Vermeulen, Nico P. E
Format:	Artikel
Sprache:	eng
Schlagworte:	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - chemistry 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - metabolism Animals Chlorides - chemistry Chlorides - metabolism Computer Simulation Epoxy Compounds - chemistry Epoxy Compounds - metabolism Glutathione - metabolism Glutathione Transferase - chemistry Glutathione Transferase - metabolism Isoenzymes - chemistry Isoenzymes - metabolism Models, Molecular Oxides - chemistry Oxides - metabolism Rats Substrate Specificity Templates, Genetic
Online-Zugang:	Volltext
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