Pentamidine Congeners. 2. 2-Butene-Bridged Aromatic Diamidines and Diimidazolines as Potential Anti-Pneumocystis carinii Pneumonia Agents

We have synthesized cis and trans geometric isomers 1-8 as semirigid congeners of pentamidine. Compounds 1-4 were more potent than pentamidine in treating Pneumocystis carinii pneumonia in immunosuppressed rats. These compounds also demonstrated no clinical toxicity or histopathologic abnormalities....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1994-12, Vol.37 (26), p.4554-4557
Hauptverfasser:	Donkor, Isaac O, Tidwell, Richard R, Jones, Susan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA - metabolism Pentamidine - analogs & derivatives Pentamidine - metabolism Pentamidine - therapeutic use Pneumocystis carinii Pneumonia, Pneumocystis - drug therapy Rats Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!