Effect of modulation of protein kinase C activity on cisplatin cytotoxicity in cisplatin-resistant and cisplatin-sensitive human osteosarcoma cells

The effect of modulation of protein kinase C (PKC) activity by 12- O-tetradecanoylphorbol-13-acetate (TPA) on cisplatin cytotoxicity was examined in a human osteosarcoma U2-OS cell line and in a U2-OS variant (U2-OS/Pt) selected after continuous exposure to increasing concentrations of cisplatin. U2...

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Veröffentlicht in:	Cancer letters 1993-08, Vol.72 (1), p.53-58
Hauptverfasser:	Perego, Paola, Casati, Greta, Gambetta, Romolo A., Soranzo, Carla, Zunino, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Chemotherapy Cisplatin - pharmacology cisplatin resistance Drug Interactions Drug Resistance Humans Medical sciences Osteosarcoma - drug therapy Osteosarcoma - metabolism Pharmacology. Drug treatments PKC modulation Protein Kinase C - drug effects Protein Kinase C - physiology Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured - drug effects U2-OS cell line
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