Advances in the Molecular Analysis of Breast Cancer: Pathway Toward Personalized Medicine
Breast cancer is a heterogeneous disease that encompasses a wide range of clinical behaviors and histological and molecular variants. It is the most common type of cancer affecting women worldwide and is the second leading cause of cancer death. A comprehensive literature search was performed to exp...
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| Veröffentlicht in: | Cancer control 2015-04, Vol.22 (2), p.211-219 |
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| creator | Rosa, Marilin |
| description | Breast cancer is a heterogeneous disease that encompasses a wide range of clinical behaviors and histological and molecular variants. It is the most common type of cancer affecting women worldwide and is the second leading cause of cancer death.
A comprehensive literature search was performed to explore the advances in molecular medicine related to the diagnosis and treatment of breast cancer.
During the last few decades, advances in molecular medicine have changed the landscape of cancer treatment as new molecular tests complement and, in many instances, exceed traditional methods for determining patient prognosis and response to treatment options. Personalized medicine is becoming the standard of care around the world. Developments in molecular profiling, genomic analysis, and the discovery of targeted drug therapies have significantly improved patient survival rates and quality of life.
This review highlights what pathologists need to know about current molecular tests for classification and prognostic/ predictive assessment of breast carcinoma as well as their role as part of the medical team. |
| doi_str_mv | 10.1177/107327481502200213 |
| format | Article |
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During the last few decades, advances in molecular medicine have changed the landscape of cancer treatment as new molecular tests complement and, in many instances, exceed traditional methods for determining patient prognosis and response to treatment options. Personalized medicine is becoming the standard of care around the world. Developments in molecular profiling, genomic analysis, and the discovery of targeted drug therapies have significantly improved patient survival rates and quality of life.
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A comprehensive literature search was performed to explore the advances in molecular medicine related to the diagnosis and treatment of breast cancer.
During the last few decades, advances in molecular medicine have changed the landscape of cancer treatment as new molecular tests complement and, in many instances, exceed traditional methods for determining patient prognosis and response to treatment options. Personalized medicine is becoming the standard of care around the world. Developments in molecular profiling, genomic analysis, and the discovery of targeted drug therapies have significantly improved patient survival rates and quality of life.
This review highlights what pathologists need to know about current molecular tests for classification and prognostic/ predictive assessment of breast carcinoma as well as their role as part of the medical team.</description><subject>Biomarkers, Tumor</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Care and treatment</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Genetic aspects</subject><subject>Genetic variation</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Immunohistochemistry</subject><subject>Innovations</subject><subject>Molecular targeted therapy</subject><subject>Precision Medicine - methods</subject><subject>Prognosis</subject><subject>Protein Array Analysis</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptors, Estrogen - biosynthesis</subject><subject>Receptors, Progesterone - biosynthesis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Survival Rate</subject><issn>1073-2748</issn><issn>1526-2359</issn><issn>1073-2748</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0U1LBCEcBnCJovcv0CGEILpM-TIzznTblt6gqEMdOg2O_m0NdyydKbZPn8tWFIUHRX-PoA9CO5QcUirEESWCM5FXtCCMEcIoX0LrtGBlxnhRL6d1AtlcrKGNGJ8SITnPV9EaK0lZiVKso4eRfpWdgohth_sJ4GvvQA1OBjzqpJtFG7E3-CSAjD0ez2k4xreyn7zJGb7zbzJofAsh-qTtO2h8Ddoq28EWWjHSRdj-nDfR_dnp3fgiu7o5vxyPrjJVUNpnCnReM8OEqTmIUlJVAShSFqDbnAqmRZvOcqppnVdtrZWUTAAVVWsMJ0zxTXSwuPc5-JcBYt9MbVTgnOzAD7GhZVURUhMhEt1b0EfpoLGd8X2Qas6bUc6L9D8FKZI6_EeloWFqle_A2LT_K7D_IzAB6fpJ9G7ore_ib8gWUAUfYwDTPAc7lWHWUNLMK23-VppCu5_vG9op6O_IV4f8A5fdmQE</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Rosa, Marilin</creator><general>H. Lee Moffitt Cancer Center and Research Institute</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201504</creationdate><title>Advances in the Molecular Analysis of Breast Cancer: Pathway Toward Personalized Medicine</title><author>Rosa, Marilin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-ced492f27f93e76a1c8eec065edb4172d7b27f41d1948b9dcaa27e178bff302c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biomarkers, Tumor</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Care and treatment</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Genetic aspects</topic><topic>Genetic variation</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Immunohistochemistry</topic><topic>Innovations</topic><topic>Molecular targeted therapy</topic><topic>Precision Medicine - methods</topic><topic>Prognosis</topic><topic>Protein Array Analysis</topic><topic>Receptor, ErbB-2 - genetics</topic><topic>Receptors, Estrogen - biosynthesis</topic><topic>Receptors, Progesterone - biosynthesis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rosa, Marilin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosa, Marilin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in the Molecular Analysis of Breast Cancer: Pathway Toward Personalized Medicine</atitle><jtitle>Cancer control</jtitle><addtitle>Cancer Control</addtitle><date>2015-04</date><risdate>2015</risdate><volume>22</volume><issue>2</issue><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>1073-2748</issn><eissn>1526-2359</eissn><eissn>1073-2748</eissn><abstract>Breast cancer is a heterogeneous disease that encompasses a wide range of clinical behaviors and histological and molecular variants. It is the most common type of cancer affecting women worldwide and is the second leading cause of cancer death.
A comprehensive literature search was performed to explore the advances in molecular medicine related to the diagnosis and treatment of breast cancer.
During the last few decades, advances in molecular medicine have changed the landscape of cancer treatment as new molecular tests complement and, in many instances, exceed traditional methods for determining patient prognosis and response to treatment options. Personalized medicine is becoming the standard of care around the world. Developments in molecular profiling, genomic analysis, and the discovery of targeted drug therapies have significantly improved patient survival rates and quality of life.
This review highlights what pathologists need to know about current molecular tests for classification and prognostic/ predictive assessment of breast carcinoma as well as their role as part of the medical team.</abstract><cop>United States</cop><pub>H. Lee Moffitt Cancer Center and Research Institute</pub><pmid>26068767</pmid><doi>10.1177/107327481502200213</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Cancer control, 2015-04, Vol.22 (2), p.211-219 |
| issn | 1073-2748 1526-2359 1073-2748 |
| language | eng |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers, Tumor Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Care and treatment Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - genetics Genetic aspects Genetic variation Humans Identification and classification Immunohistochemistry Innovations Molecular targeted therapy Precision Medicine - methods Prognosis Protein Array Analysis Receptor, ErbB-2 - genetics Receptors, Estrogen - biosynthesis Receptors, Progesterone - biosynthesis Reverse Transcriptase Polymerase Chain Reaction Survival Rate |
| title | Advances in the Molecular Analysis of Breast Cancer: Pathway Toward Personalized Medicine |
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