Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2007 and 2011 staging systems: a pooled analysis of individual patient data

Summary Background There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease [GOLD] 2007) have traditionally used forced expiratory volume in 1 s (FEV1 ) for staging,...

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Veröffentlicht in:	The lancet respiratory medicine 2015-06, Vol.3 (6), p.443-450
Hauptverfasser:	Soriano, Joan B, Dr, Lamprecht, Bernd, MD, Ramírez, Ana S, Martinez-Camblor, Pablo, PhD, Kaiser, Bernhard, PhD, Alfageme, Inmaculada, MD, Almagro, Pere, MD, Casanova, Ciro, MD, Esteban, Cristobal, MD, Soler-Cataluña, Juan J, MD, de-Torres, Juan P, MD, Miravitlles, Marc, MD, Celli, Bartolome R, MD, Marin, Jose M, MD, Puhan, Milo A, MD, Sobradillo, Patricia, MD, Lange, Peter, MD, Sternberg, Alice L, ScM, Garcia-Aymerich, Judith, MD, Turner, Alice M, MD, Han, MeiLan K, MD, Langhammer, Arnulf, MD, Leivseth, Linda, PhD, Bakke, Per, MD, Johannessen, Ane, MD, Roche, Nicolas, MD, Sin, Don D, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Female Forced Expiratory Volume Humans Male Middle Aged Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - mortality Pulmonary/Respiratory Risk Severity of Illness Index Survival Analysis
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Zusammenfassung:	Summary Background There is no universal consensus on the best staging system for chronic obstructive pulmonary disease (COPD). Although documents (eg, the Global Initiative for Chronic Obstructive Lung Disease [GOLD] 2007) have traditionally used forced expiratory volume in 1 s (FEV1 ) for staging, clinical parameters have been added to some guidelines (eg, GOLD 2011) to improve patient management. As part of the COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aimed to investigate how individual patients were categorised by GOLD 2007 and 2011, and compare the prognostic accuracy of the staging documents for mortality. Methods We searched reports published from Jan 1, 2008, to Dec 31, 2014. Using data from cohorts that agreed to participate and had a minimum amount of information needed for GOLD 2007 and 2011, we did a patient-based pooled analysis of existing data. With use of raw data, we recalculated all participant assignments to GOLD 2007 I–IV classes, and GOLD 2011 A–D stages. We used survival analysis, C statistics, and non-parametric regression to model time-to-death data and compare GOLD 2007 and GOLD 2011 staging systems to predict mortality. Findings We collected individual data for 15 632 patients from 22 COPD cohorts from seven countries, totalling 70 184 person-years. Mean age of the patients was 63·9 years (SD 10·1); 10 751 (69%) were men. Based on FEV1 alone (GOLD 2007), 2424 (16%) patients had mild (I), 7142 (46%) moderate (II), 4346 (28%) severe (III), and 1670 (11%) very severe (IV) disease. We compared staging with the GOLD 2007 document with that of the new GOLD 2011 system in 14 660 patients: 5548 (38%) were grade A, 2733 (19%) were grade B, 1835 (13%) were grade C, and 4544 (31%) were grade D. GOLD 2011 shifted the overall COPD severity distribution to more severe categories. There were nearly three times more COPD patients in stage D than in former stage IV (p
ISSN:	2213-2600 2213-2619
DOI:	10.1016/S2213-2600(15)00157-5