Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

•We review work on the signals affecting the commitment of γδ versus αβ lineage T cells.•We review the interplay between TCR signal strength and E protein activity.•We review how the acquisition of different γδ T cell effector functions is regulated.•We examined whether γδ17 cells can be generated f...

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