Toll-like receptor 2 and -4 are involved in the pathogenesis of the Guillain-Barré syndrome

Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system characterized by weakness in the limbs. To date, numerous hypotheses have been suggested to explain the pathogenesis of GBS; however, the pathogenesis of GBS remains to be elucidated. The aim of the present stud...

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Veröffentlicht in:	Molecular medicine reports 2015-08, Vol.12 (2), p.3207-3213
Hauptverfasser:	DU, YAMEI, ZHANG, GUOJUN, ZHANG, ZAIQIANG, WANG, QIAN, MA, RUIMIN, ZHANG, LIMIN, FAN, FEI, LI, YOURAN, WANG, MENG, LV, HONG, KANG, XIXIONG
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-ganglioside antibody Antibodies Antibodies, Antiphospholipid - blood Case-Control Studies Cell culture Cytokines Disease Progression Gene Expression Regulation Genetic aspects Guillain-Barre syndrome Guillain-Barre Syndrome - blood Guillain-Barre Syndrome - genetics Guillain-Barre Syndrome - immunology Guillain-Barre Syndrome - pathology Guillain-Barré syndrome Humans Hypotheses IL-1β Immunoglobulin G - blood Immunoglobulin M Immunoglobulin M - blood Immunoglobulins Interleukin-1beta - biosynthesis Interleukin-1beta - blood Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - pathology Ligands Limbs Messenger RNA mRNA MyD88 protein Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - immunology Nervous system NF-kappa B - genetics NF-kappa B - immunology Pathogenesis Peripheral blood mononuclear cells Polymerase chain reaction Primary Cell Culture Risk factors RNA, Messenger - genetics RNA, Messenger - immunology Severity of Illness Index Signal Transduction Studies TLR2 protein TLR4 protein Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-like receptors Tumor necrosis factor Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF
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