Smooth Muscle Peroxisome Proliferator–Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo

Vascular inflammation plays a critical role in the pathogenesis of cerebral aneurysms. Peroxisome proliferator–activated receptor γ (PPARγ) protects against vascular inflammation and atherosclerosis, whereas dominant-negative mutations in PPARγ promote atherosclerosis and vascular dysfunction. We te...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2015-07, Vol.66 (1), p.211-220
Hauptverfasser:	Hasan, David M, Starke, Robert M, Gu, He, Wilson, Katina, Chu, Yi, Chalouhi, Nohra, Heistad, Donald D, Faraci, Frank M, Sigmund, Curt D
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm, Ruptured - genetics Aneurysm, Ruptured - physiopathology Angiotensin II - toxicity Anilides - pharmacology Anilides - toxicity Animals Cerebral Arteries - metabolism Endothelium, Vascular - metabolism Gene Expression Regulation - physiology Genes, Dominant Hypertension - chemically induced Hypertension - complications Inflammation Mediators - metabolism Intracranial Aneurysm - chemically induced Intracranial Aneurysm - genetics Intracranial Aneurysm - physiopathology Mice Mice, Transgenic Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Mutation Myocytes, Smooth Muscle - metabolism Organ Specificity Pancreatic Elastase - toxicity PPAR gamma - agonists PPAR gamma - antagonists & inhibitors PPAR gamma - deficiency PPAR gamma - genetics PPAR gamma - physiology Subarachnoid Hemorrhage - etiology Subarachnoid Hemorrhage - prevention & control Thiazolidinediones - pharmacology Up-Regulation Vasculitis - complications Vasculitis - genetics Vasculitis - metabolism Vasculitis - pathology
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