Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury

Propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function. However, whether propofol is able to protect the blood brain barrier (BBB) and the underlying mechanisms have remained to b...

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Veröffentlicht in:	Molecular medicine reports 2015-08, Vol.12 (2), p.2049-2055
Hauptverfasser:	JI, FENG-TAO, LIANG, JIAN-JUN, MIAO, LI-PING, WU, QIANG, CAO, MING-HUI
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Intravenous - therapeutic use Animals Apoptosis Aquaporin 4 Aquaporin 4 - analysis Aquaporin 4 - metabolism Aquaporins Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain - drug effects Brain - metabolism Brain - pathology Brain injury Brain Ischemia - drug therapy Brain Ischemia - metabolism Brain Ischemia - pathology c-Jun N-terminal kinase c-Jun protein Carotid arteries Cerebral blood flow Cerebral ischemia Drug therapy Edema Embolism Gelatinase B Genetic aspects Health aspects Intravenous administration Ischemia ischemia reperfusion injury JNK protein Laboratory animals MAP Kinase Kinase 4 - analysis MAP Kinase Kinase 4 - metabolism Matrix metalloproteinase Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - metabolism Metalloproteinase Narcotics - therapeutic use Permeability Phosphorylation Phosphorylation - drug effects Physiological aspects Physiology Polyclonal antibodies Propofol Propofol - therapeutic use Rats Rats, Wistar Reperfusion Reperfusion Injury - drug therapy Reperfusion Injury - metabolism Reperfusion Injury - pathology Risk factors Rodents Stroke Studies Surgery Transcription factors Veins & arteries Water content
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