Suppression of phosphatase and tensin homolog protects insulin-resistant cells from apoptosis

In the present study, a glucosamine-induced model of insulin-resistant skeletal muscle cells was established in order to investigate the effect of inhibition of phosphatase and tensin homolog (PTEN)/5′-adenosine monophosphate-activated protein kinase (AMPK) on these cells. The glucosamine-induced in...

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Veröffentlicht in:	Molecular medicine reports 2015-08, Vol.12 (2), p.2695-2700
Hauptverfasser:	WANG, DI-FEI, YANG, HUI-JING, GU, JIAN-QIU, CAO, YAN-LI, MENG, XIN, WANG, XIAO-LI, LIN, YI-CHEN, GAO, MING
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine kinase AMP Animals Apoptosis Apoptosis - drug effects Biotechnology Cells, Cultured Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Flow cytometry Glucosamine Glucose metabolism Glucose oxidase Glucose transporter Glucose Transporter Type 4 - metabolism Hypoglycemic Agents - pharmacology Immunofluorescence Insulin Insulin - metabolism Insulin Resistance Kinases Metformin Metformin - pharmacology Muscle, Skeletal - cytology Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Peroxidase phosphatase and tensin homolog Phosphatases Protein kinase Protein Transport - drug effects PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - metabolism PTEN protein Rats Rodents Skeletal muscle skeletal muscle cells Tensin Up-Regulation - drug effects Vanadates - pharmacology Western blotting
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