Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy
Mycobacterial spindle cell pseudotumor (MSP) represents a rare, non‐malignant, mass‐forming reaction to various mycobacterial infections, typically occurring in immunocompromised patients. It is characterized by the proliferation of spindle‐shaped fibrohistiocytic cells without the formation of epit...
Gespeichert in:
| Veröffentlicht in: | Transplant infectious disease 2015-06, Vol.17 (3), p.424-428 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 428 |
|---|---|
| container_issue | 3 |
| container_start_page | 424 |
| container_title | Transplant infectious disease |
| container_volume | 17 |
| creator | Franco, M. Amoroso, A. Burke, A.P. Britt, E.J. Reed, R.M. |
| description | Mycobacterial spindle cell pseudotumor (MSP) represents a rare, non‐malignant, mass‐forming reaction to various mycobacterial infections, typically occurring in immunocompromised patients. It is characterized by the proliferation of spindle‐shaped fibrohistiocytic cells without the formation of epithelioid granulomas. Without staining for acid‐fast bacilli, histological distinction from other spindle cell lesions, including malignancy, can be difficult. Most of the MSP cases reported in the literature have involved lymph nodes, skin, spleen, or bone marrow, but rarely involve the lung. MSP predominately occurs in patients who are immunosuppressed. We present a patient with MSP of the transplanted lung caused by non‐tuberculous mycobacteria, in whom both the natural course of the untreated pseudotumor as well as the response to antimycobacterial treatments were observed. |
| doi_str_mv | 10.1111/tid.12390 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1687995390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3709976321</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3530-57c13c067664c5916d945e6566e028b35bacf4bc1bf650f0c70d169e2d81d73b3</originalsourceid><addsrcrecordid>eNp1kU1vFSEYhYmxsR-68A8YEjd2MS0MAzO4M7XVJk10UdcTBt5paRgY-Uhzt_5yufe2LkzKBvLy5OS85yD0npIzWs95tuaMtkySV-iIMikbRkT7evcemrbt2SE6TumBENrLTr5Bhy0fOiF6eoT-_CxuCV7FDV42OkxKZ4hWOZxW640DrME5vCYoJuSyhIitxwq74u9wjsqn1Smf8aqyBZ8_4zWGuwgp2eDxo833oWSc7yGqdYOVN7j-rcEnwDk8z9-ig1m5BO-e7hP06-ry9uJ7c_Pj2_XFl5tGM85Iw3tNmSaiF6LTXFJhZMdBcCGAtMPEePU-d5Om0yw4mYnuiaFCQmsGano2sRP0aa9bPf4ukPK42LRdT3kIJY1UDL2UvMZY0Y__oQ-hRF_d7SgiKOVb6nRP6RhSijCPa7RLjXKkZNwWM9Zixl0xlf3wpFimBcw_8rmJCpzvgUfrYPOy0nh7_XUv-Re-_Jms</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687061150</pqid></control><display><type>article</type><title>Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Franco, M. ; Amoroso, A. ; Burke, A.P. ; Britt, E.J. ; Reed, R.M.</creator><creatorcontrib>Franco, M. ; Amoroso, A. ; Burke, A.P. ; Britt, E.J. ; Reed, R.M.</creatorcontrib><description>Mycobacterial spindle cell pseudotumor (MSP) represents a rare, non‐malignant, mass‐forming reaction to various mycobacterial infections, typically occurring in immunocompromised patients. It is characterized by the proliferation of spindle‐shaped fibrohistiocytic cells without the formation of epithelioid granulomas. Without staining for acid‐fast bacilli, histological distinction from other spindle cell lesions, including malignancy, can be difficult. Most of the MSP cases reported in the literature have involved lymph nodes, skin, spleen, or bone marrow, but rarely involve the lung. MSP predominately occurs in patients who are immunosuppressed. We present a patient with MSP of the transplanted lung caused by non‐tuberculous mycobacteria, in whom both the natural course of the untreated pseudotumor as well as the response to antimycobacterial treatments were observed.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/tid.12390</identifier><identifier>PMID: 25846671</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Aged ; Anti-Bacterial Agents - administration & dosage ; Azithromycin - administration & dosage ; Bone marrow ; Disease Progression ; Ethambutol - administration & dosage ; Female ; Fluoroquinolones - administration & dosage ; Humans ; Immunocompromised Host ; Lung - diagnostic imaging ; Lung - surgery ; lung transplant ; Lung Transplantation ; Lymph nodes ; Lymphatic system ; mycobacterial spindle cell pseudotumor ; Mycobacterium avium complex ; Mycobacterium avium Complex - isolation & purification ; Mycobacterium avium-intracellulare Infection - diagnostic imaging ; Mycobacterium avium-intracellulare Infection - drug therapy ; Mycobacterium avium-intracellulare Infection - microbiology ; non‐tuberculous mycobacteria ; Treatment Outcome</subject><ispartof>Transplant infectious disease, 2015-06, Vol.17 (3), p.424-428</ispartof><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2015 Wiley Periodicals, Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3530-57c13c067664c5916d945e6566e028b35bacf4bc1bf650f0c70d169e2d81d73b3</citedby><cites>FETCH-LOGICAL-c3530-57c13c067664c5916d945e6566e028b35bacf4bc1bf650f0c70d169e2d81d73b3</cites><orcidid>0000-0002-4681-7070</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftid.12390$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftid.12390$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25846671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franco, M.</creatorcontrib><creatorcontrib>Amoroso, A.</creatorcontrib><creatorcontrib>Burke, A.P.</creatorcontrib><creatorcontrib>Britt, E.J.</creatorcontrib><creatorcontrib>Reed, R.M.</creatorcontrib><title>Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>Mycobacterial spindle cell pseudotumor (MSP) represents a rare, non‐malignant, mass‐forming reaction to various mycobacterial infections, typically occurring in immunocompromised patients. It is characterized by the proliferation of spindle‐shaped fibrohistiocytic cells without the formation of epithelioid granulomas. Without staining for acid‐fast bacilli, histological distinction from other spindle cell lesions, including malignancy, can be difficult. Most of the MSP cases reported in the literature have involved lymph nodes, skin, spleen, or bone marrow, but rarely involve the lung. MSP predominately occurs in patients who are immunosuppressed. We present a patient with MSP of the transplanted lung caused by non‐tuberculous mycobacteria, in whom both the natural course of the untreated pseudotumor as well as the response to antimycobacterial treatments were observed.</description><subject>Aged</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Azithromycin - administration & dosage</subject><subject>Bone marrow</subject><subject>Disease Progression</subject><subject>Ethambutol - administration & dosage</subject><subject>Female</subject><subject>Fluoroquinolones - administration & dosage</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - surgery</subject><subject>lung transplant</subject><subject>Lung Transplantation</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>mycobacterial spindle cell pseudotumor</subject><subject>Mycobacterium avium complex</subject><subject>Mycobacterium avium Complex - isolation & purification</subject><subject>Mycobacterium avium-intracellulare Infection - diagnostic imaging</subject><subject>Mycobacterium avium-intracellulare Infection - drug therapy</subject><subject>Mycobacterium avium-intracellulare Infection - microbiology</subject><subject>non‐tuberculous mycobacteria</subject><subject>Treatment Outcome</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1vFSEYhYmxsR-68A8YEjd2MS0MAzO4M7XVJk10UdcTBt5paRgY-Uhzt_5yufe2LkzKBvLy5OS85yD0npIzWs95tuaMtkySV-iIMikbRkT7evcemrbt2SE6TumBENrLTr5Bhy0fOiF6eoT-_CxuCV7FDV42OkxKZ4hWOZxW640DrME5vCYoJuSyhIitxwq74u9wjsqn1Smf8aqyBZ8_4zWGuwgp2eDxo833oWSc7yGqdYOVN7j-rcEnwDk8z9-ig1m5BO-e7hP06-ry9uJ7c_Pj2_XFl5tGM85Iw3tNmSaiF6LTXFJhZMdBcCGAtMPEePU-d5Om0yw4mYnuiaFCQmsGano2sRP0aa9bPf4ukPK42LRdT3kIJY1UDL2UvMZY0Y__oQ-hRF_d7SgiKOVb6nRP6RhSijCPa7RLjXKkZNwWM9Zixl0xlf3wpFimBcw_8rmJCpzvgUfrYPOy0nh7_XUv-Re-_Jms</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Franco, M.</creator><creator>Amoroso, A.</creator><creator>Burke, A.P.</creator><creator>Britt, E.J.</creator><creator>Reed, R.M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4681-7070</orcidid></search><sort><creationdate>201506</creationdate><title>Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy</title><author>Franco, M. ; Amoroso, A. ; Burke, A.P. ; Britt, E.J. ; Reed, R.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3530-57c13c067664c5916d945e6566e028b35bacf4bc1bf650f0c70d169e2d81d73b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Azithromycin - administration & dosage</topic><topic>Bone marrow</topic><topic>Disease Progression</topic><topic>Ethambutol - administration & dosage</topic><topic>Female</topic><topic>Fluoroquinolones - administration & dosage</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - surgery</topic><topic>lung transplant</topic><topic>Lung Transplantation</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>mycobacterial spindle cell pseudotumor</topic><topic>Mycobacterium avium complex</topic><topic>Mycobacterium avium Complex - isolation & purification</topic><topic>Mycobacterium avium-intracellulare Infection - diagnostic imaging</topic><topic>Mycobacterium avium-intracellulare Infection - drug therapy</topic><topic>Mycobacterium avium-intracellulare Infection - microbiology</topic><topic>non‐tuberculous mycobacteria</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franco, M.</creatorcontrib><creatorcontrib>Amoroso, A.</creatorcontrib><creatorcontrib>Burke, A.P.</creatorcontrib><creatorcontrib>Britt, E.J.</creatorcontrib><creatorcontrib>Reed, R.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franco, M.</au><au>Amoroso, A.</au><au>Burke, A.P.</au><au>Britt, E.J.</au><au>Reed, R.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2015-06</date><risdate>2015</risdate><volume>17</volume><issue>3</issue><spage>424</spage><epage>428</epage><pages>424-428</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>Mycobacterial spindle cell pseudotumor (MSP) represents a rare, non‐malignant, mass‐forming reaction to various mycobacterial infections, typically occurring in immunocompromised patients. It is characterized by the proliferation of spindle‐shaped fibrohistiocytic cells without the formation of epithelioid granulomas. Without staining for acid‐fast bacilli, histological distinction from other spindle cell lesions, including malignancy, can be difficult. Most of the MSP cases reported in the literature have involved lymph nodes, skin, spleen, or bone marrow, but rarely involve the lung. MSP predominately occurs in patients who are immunosuppressed. We present a patient with MSP of the transplanted lung caused by non‐tuberculous mycobacteria, in whom both the natural course of the untreated pseudotumor as well as the response to antimycobacterial treatments were observed.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>25846671</pmid><doi>10.1111/tid.12390</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-4681-7070</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1398-2273 |
| ispartof | Transplant infectious disease, 2015-06, Vol.17 (3), p.424-428 |
| issn | 1398-2273 1399-3062 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1687995390 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aged Anti-Bacterial Agents - administration & dosage Azithromycin - administration & dosage Bone marrow Disease Progression Ethambutol - administration & dosage Female Fluoroquinolones - administration & dosage Humans Immunocompromised Host Lung - diagnostic imaging Lung - surgery lung transplant Lung Transplantation Lymph nodes Lymphatic system mycobacterial spindle cell pseudotumor Mycobacterium avium complex Mycobacterium avium Complex - isolation & purification Mycobacterium avium-intracellulare Infection - diagnostic imaging Mycobacterium avium-intracellulare Infection - drug therapy Mycobacterium avium-intracellulare Infection - microbiology non‐tuberculous mycobacteria Treatment Outcome |
| title | Pulmonary mycobacterial spindle cell pseudotumor in a lung transplant patient: progression without therapy and response to therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T05%3A55%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pulmonary%20mycobacterial%20spindle%20cell%20pseudotumor%20in%20a%20lung%20transplant%20patient:%20progression%20without%20therapy%20and%20response%20to%20therapy&rft.jtitle=Transplant%20infectious%20disease&rft.au=Franco,%20M.&rft.date=2015-06&rft.volume=17&rft.issue=3&rft.spage=424&rft.epage=428&rft.pages=424-428&rft.issn=1398-2273&rft.eissn=1399-3062&rft_id=info:doi/10.1111/tid.12390&rft_dat=%3Cproquest_cross%3E3709976321%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1687061150&rft_id=info:pmid/25846671&rfr_iscdi=true |