Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice

Epilepsy is a chronic neurological disorder and generally associated with certain psychiatric comorbidities. Among several comorbidities depressive behavior and cognitive impairment has been reported to be most debilitating comorbidity associated with epilepsy. This study was envisaged to evaluate t...

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Veröffentlicht in:	European journal of pharmacology 2013-03, Vol.704 (1-3), p.33-40
Hauptverfasser:	Choudhary, Kailash M., Mishra, Awanish, Poroikov, Vladimir V., Goel, Rajesh Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholinesterase Acetylcholinesterase - metabolism Animals Anticonvulsants - therapeutic use Behavior, Animal - drug effects brain Brain - drug effects Brain - metabolism comorbidity Convulsants Curcumin Curcumin - therapeutic use Depression Depression - drug therapy Depression - physiopathology epilepsy Epileptic comorbidities Hindlimb Suspension Learning - drug effects Learning and memory deficit Male memory Memory Disorders - drug therapy Memory Disorders - physiopathology Mice Nitrates - metabolism Nitrites - metabolism norepinephrine Norepinephrine - metabolism Pentylenetetrazole phenytoin PTZ kindling Seizures - chemically induced Seizures - drug therapy Seizures - physiopathology serotonin Serotonin - metabolism
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