Senescence-related genes possibly responsible for poor liver regeneration after hepatectomy in elderly patients

Background and Aim Liver regeneration likely decreases with age by an, as yet, incompletely understood mechanism, restricting the extent of hepatectomy. We therefore analyzed the effect of aging on liver regeneration and investigated mechanisms associate with poor regeneration of human liver. Method...

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Veröffentlicht in:	Journal of gastroenterology and hepatology 2014-05, Vol.29 (5), p.1102-1108
Hauptverfasser:	Zhu, Chengzhan, Ikemoto, Tetsuya, Utsunomiya, Tohru, Yamada, Shinichiro, Morine, Yuji, Imura, Satoru, Arakawa, Yusuke, Takasu, Chie, Ishikawa, Daichi, Shimada, Mitsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - genetics Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cyclin-Dependent Kinase Inhibitor p16 Down-Regulation - genetics Female Gene Expression - genetics Hepatectomy Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism HGF Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism liver regeneration Liver Regeneration - genetics Male Met Middle Aged Neoplasm Proteins - genetics Neoplasm Proteins - metabolism p16 Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Reverse Transcriptase Polymerase Chain Reaction senescence Sirtuin 1 - genetics Sirtuin 1 - metabolism Up-Regulation - genetics
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